Featured Research

from universities, journals, and other organizations

New breakthrough in fight against lethal CCHF virus

Date:
May 21, 2010
Source:
Society for General Microbiology
Summary:
Crimean-Congo haemorrhagic fever (CCHF) virus is a rare but serious human infection that causes internal bleeding, organ failure and ultimately death. Scientists have developed a new model to study CCHF which should enhance the development of vaccines and antivirals against this deadly disease.

Crimean-Congo haemorrhagic fever (CCHF) virus is a rare but serious human infection that causes internal bleeding, organ failure and ultimately death. Scientists writing in the Journal of General Virology have developed a new model to study CCHF which should enhance the development of vaccines and antivirals against this deadly disease.

CCHF virus is a tick-borne pathogen that infects (but does not cause disease in) wild and domestic animals in many countries in Africa, Europe and Asia. Humans may become infected from a tick bite or through direct contact with blood or other infected tissues from livestock such as cattle, sheep and goats. CCHF infections in humans lead to serious disease and have a fatality rate of approximately 30%. New vaccines and treatments are urgently needed to combat the CCHF virus, but their development is being hindered by a lack of suitable animal models for testing.

Scientists from the Swedish Institute for Infectious Disease Control, Solna, Sweden have now found that immune-deficient mice can be used as a model to study how CCHF virus behaves in humans. The group discovered that mice unresponsive to key antiviral molecules produced by their innate immune system developed classic symptoms of CCHF viral infection that were fatal.

Dr Ali Mirazimi who led the study, believes the groups' work will contribute enormously to vaccine and antiviral development studies. "To date there is no safe or effective vaccine available for human use or a specific antiviral for CCHF virus," he said. "A reliable animal model is the only way that the safety and effectiveness of a potential vaccine or antiviral treatment can be properly evaluated," he explained.

New strategies to control the spread of the CCHF virus could also have huge economic impact for farmers in developing countries. "As the virus can be transmitted to humans via infected animal tissues, farmers who breed food-producing animals can lose huge amounts of money if their stocks have to be culled," explained Dr Mirazimi.


Story Source:

The above story is based on materials provided by Society for General Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Bereczky, G. Lindegren, H. Karlberg, S. Akerstrom, J. Klingstrom, A. Mirazimi. Crimean Congo haemorrhagic fever virus infection is lethal for adult 1 type I interferon receptor knock-out mice. Journal of General Virology, 2010; DOI: 10.1099/vir.0.019034-0

Cite This Page:

Society for General Microbiology. "New breakthrough in fight against lethal CCHF virus." ScienceDaily. ScienceDaily, 21 May 2010. <www.sciencedaily.com/releases/2010/05/100517204401.htm>.
Society for General Microbiology. (2010, May 21). New breakthrough in fight against lethal CCHF virus. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2010/05/100517204401.htm
Society for General Microbiology. "New breakthrough in fight against lethal CCHF virus." ScienceDaily. www.sciencedaily.com/releases/2010/05/100517204401.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins