Featured Research

from universities, journals, and other organizations

Going from strength to strength: effects of growth hormone on muscle

Date:
October 1, 2010
Source:
Journal of Clinical Investigation
Summary:
Growth hormone has multiple effects on skeletal muscle, including promoting growth and regeneration. It is not clear, however, which effects are direct and which are mediated via induction of the protein IGF-1. New mouse research shows that growth hormone control of skeletal muscle development is IGF-1 dependent, whereas other effects are IGF-1independent.

Growth hormone is used to treat children's growth disorders and has been used by some sports men and women to promote muscle growth and regeneration. This is because it coordinates skeletal muscle development, nutrient uptake, and nutrient utilization. It is not clear, however, which of these effects are direct and which are indirectly mediated via growth hormone induction of the protein IGF-1.

Now, however, a team of researchers, led by Thomas Clemens, at Johns Hopkins University School of Medicine, Baltimore, has used mice engineered to lack in their skeletal muscle either the molecule to which growth hormone binds or the molecule to which IGF-1 binds to show that growth hormone control of skeletal muscle development is dependent on IGF-1, whereas its control of nutrient uptake is independent of IGF-1.

The authors hope that with additional work, these results will guide more informed use of growth hormone or growth hormone analogs for promoting muscle development and reducing muscle loss.

The research is published in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mahendra D. Mavalli, Douglas J. DiGirolamo, Yong Fan, Ryan C. Riddle, Kenneth S. Campbell, Thomas van Groen, Stuart J. Frank, Mark A. Sperling, Karyn A. Esser, Marcas M. Bamman, Thomas L. Clemens. Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI42447

Cite This Page:

Journal of Clinical Investigation. "Going from strength to strength: effects of growth hormone on muscle." ScienceDaily. ScienceDaily, 1 October 2010. <www.sciencedaily.com/releases/2010/10/101001144023.htm>.
Journal of Clinical Investigation. (2010, October 1). Going from strength to strength: effects of growth hormone on muscle. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2010/10/101001144023.htm
Journal of Clinical Investigation. "Going from strength to strength: effects of growth hormone on muscle." ScienceDaily. www.sciencedaily.com/releases/2010/10/101001144023.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com
House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Uganda on Alert for Ebola but No Confirmed Cases

Uganda on Alert for Ebola but No Confirmed Cases

AFP (July 31, 2014) Uganda's health minister said on Thursday that there are no confirmed cases of Ebola in the country, but that it remained on alert for cases of the deadly virus. Uganda has suffered Ebola outbreaks in the past, most recently in 2012. Duration: 00:59 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins