Featured Research

from universities, journals, and other organizations

Immune cells deploy traps to catch and kill pathogens

Date:
October 26, 2010
Source:
Rockefeller University Press
Summary:
A new study reveals that two enzymes help immune cells deploy pathogen-killing traps by unraveling and using the chromatin (DNA and its associated proteins) contained in the cells' nuclei to form defensive webs. The study appears online on Oct. 25 in the Journal of Cell Biology.

A new study reveals that two enzymes help immune cells deploy pathogen-killing traps by unraveling and using the chromatin (DNA and its associated proteins) contained in the cells' nuclei to form defensive webs.

Related Articles


The study appears online on October 25 in The Journal of Cell Biology.

Neutrophils, the most common type of white blood cells, are difficult to study because they live for only about six hours. So Arturo Zychlinsky and colleagues, from the Max Planck Institute for Infection Biology in Berlin, created a cell-free system that includes neutrophil nuclei and dollops of cytoplasm from the cells.

They found that two enzymes stashed in cytoplasmic granules enter the nucleus and join forces to unwind the chromatin and form neutrophil extracellular traps (NETs), webs of chromatin that catch and kill pathogens. The first to make the move is neutrophil elastase (NE), which promotes chromosome decondensation by breaking down two "histone" proteins that help keep chromatin tightly packaged in the nucleus.

Later in the process, myeloperoxidase (MPO) arrives at the nucleus to help NE unravel the chromatin. Exactly how MPO performs its task remains unclear, as its catalytic activity isn't required to decondense chromatin.

The researchers confirmed NE's importance for NET formation by exposing mice to Klebsiella pneumoniae bacteria. Neutrophils hustled to the lungs in control mice and in animals lacking NE. But neutrophils from the mice missing NE couldn't produce NETs to snare the bugs.

An important question to answer now, the researchers say, is how NE and MPO travel to the nucleus. The granules could merge with the nuclear membrane directly or burst and free the enzymes into the cytoplasm, from where they subsequently move to the nucleus.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Papayannopoulos, V., et al. Cytoplasmic enzymes cast NETs. J. Cell Biol., October 25, 2010 DOI: 10.1083/jcb.201006052

Cite This Page:

Rockefeller University Press. "Immune cells deploy traps to catch and kill pathogens." ScienceDaily. ScienceDaily, 26 October 2010. <www.sciencedaily.com/releases/2010/10/101025123854.htm>.
Rockefeller University Press. (2010, October 26). Immune cells deploy traps to catch and kill pathogens. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2010/10/101025123854.htm
Rockefeller University Press. "Immune cells deploy traps to catch and kill pathogens." ScienceDaily. www.sciencedaily.com/releases/2010/10/101025123854.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Feast Your Eyes: Lamb Chop Sent Into Space from UK

Feast Your Eyes: Lamb Chop Sent Into Space from UK

Reuters - Light News Video Online (Nov. 25, 2014) Take a stab at this -- stunt video shows a lamb chop's journey from an east London restaurant over 30 kilometers into space. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Cambodian Capital's Only Working Elephant to Retire in Jungle

Cambodian Capital's Only Working Elephant to Retire in Jungle

AFP (Nov. 25, 2014) Phnom Penh's only working elephant was blessed by a crowd of chanting Buddhist monks Tuesday as she prepared for a life of comfortable jungle retirement after three decades of giving rides to tourists. Duration: 00:36 Video provided by AFP
Powered by NewsLook.com
Stray Dog Follows Adventure Racing Team for 6-Day Endurance Race

Stray Dog Follows Adventure Racing Team for 6-Day Endurance Race

Buzz60 (Nov. 24, 2014) A Swedish Adventure racing team travels to try and win a world title, but comes home with something way better: a stray dog that joined the team for much of the grueling 430-mile race. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins