Featured Research

from universities, journals, and other organizations

The connection between a cell's cytoskeleton and its surface receptors

Date:
March 6, 2011
Source:
American Institute of Physics
Summary:
New findings may shed light on the mechanisms that regulate the organization of receptors on the cell surface, a critical aspect of cell signaling not well understood at this time.

CD36 trajectories in a primary human macrophage from a 10 Hz/10 s single-molecule movie. Scale bar, 2 m. Red, linear trajectories; cyan, isotropic trajectories. The linear motion of receptors, which depends on the actin meshwork and on microtubules, enhances receptor clustering in the absence of ligand, priming the macrophages to respond when exposed to ligand.
Credit: K. Jaqaman/Harvard Medical School.

New findings from researchers at Harvard Medical School in Boston and the Hospital for Sick Children in Toronto may shed light on the mechanisms that regulate the organization of receptors on the cell surface, a critical aspect of cell signaling not well understood at this time.

The group reports on their use of the macrophage protein CD36, a clustering-responsive class B scavenger receptor, as a model for studying the processes governing receptor clustering and organization. The protein is involved in a number of cellular and physiological functions that range from lipid metabolism to immunity, but it is unknown how the CD36 protein is organized in the cell (as monomers or as oligomers) and how that organization leads to its biological functions.

The researchers employed a combination of powerful tools: quantitative live-cell single-molecule imaging and biochemical/pharmacological approaches to study the dynamics, oligomerization and signaling of CD36 in primary human macrophages.

The group reports that movement of CD36 in the macrophage plasma membrane is regulated by the sub-membranous actin meshwork and by microtubules, demonstrating that these cytoskeletal components might play a critical role in receptor function, in general.

In terms of the impact of this research, lead researcher Khuloud Jaqaman says: "In the long run, establishing the relationship between receptor organization and cell signaling might aid in the development of drugs since receptors on the cell surface are the most accessible to pharmacological manipulation."

This work was funded by the National Institutes of Health, the Center for Cell Decision Processes (NIH P50), the Heart and Stroke Foundation of Ontario, and the Canadian Institutes of Health.


Story Source:

The above story is based on materials provided by American Institute of Physics. Note: Materials may be edited for content and length.


Cite This Page:

American Institute of Physics. "The connection between a cell's cytoskeleton and its surface receptors." ScienceDaily. ScienceDaily, 6 March 2011. <www.sciencedaily.com/releases/2011/03/110306141619.htm>.
American Institute of Physics. (2011, March 6). The connection between a cell's cytoskeleton and its surface receptors. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2011/03/110306141619.htm
American Institute of Physics. "The connection between a cell's cytoskeleton and its surface receptors." ScienceDaily. www.sciencedaily.com/releases/2011/03/110306141619.htm (accessed July 30, 2014).

Share This




More Plants & Animals News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Thousands Flocking to German Crop Circle

Raw: Thousands Flocking to German Crop Circle

AP (July 30, 2014) Thousands of people are trekking to a Bavarian farmer's field to check out a mysterious set of crop circles. (July 30) Video provided by AP
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Raw: Otters Enjoy Water Slides at Japan Zoo

Raw: Otters Enjoy Water Slides at Japan Zoo

AP (July 30, 2014) River otters were hitting the water slides to beat the summer heatwave on Wednesday at Ichikawa City's Zoological and Botanical Garden. (July 30) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins