Featured Research

from universities, journals, and other organizations

New type of secretory cell in the intestine

Date:
March 9, 2011
Source:
Rockefeller University Press
Summary:
The intestinal epithelium consists of four main specialized cell lineages: absorptive enterocytes and three secretory cell types known as enteroendocrine, Paneth, and goblet cells. But a rare, fifth type of intestinal cell called tuft cells also exists. Defined by the thick brush of long microvilli that project from their apical surface, tuft cells are seen in several epithelial tissues, yet little is known about their function due to a lack of tuft cell-specific markers.

Gerbe et al. define tuft cells as a new secretory lineage in the intestine. These rare cells can be distinguished from the four other main cell types of the intestinal epithelium by their co-expression of SOX9 (red) and COX1 (green). Microtubules are shown in white.
Credit: Fran็ois Gerbe

The intestinal epithelium consists of four main specialized cell lineages: absorptive enterocytes and three secretory cell types known as enteroendocrine, Paneth, and goblet cells. But a rare, fifth type of intestinal cell called tuft cells also exists. Defined by the thick brush of long microvilli that project from their apical surface, tuft cells are seen in several epithelial tissues, yet little is known about their function due to a lack of tuft cell-specific markers.

Related Articles


In the March 7 issue of The Journal of Cell Biology, a team of French researchers led by Philippe Jay identified a unique "signature" of proteins expressed by tuft cells. Like other intestinal cell types, tuft cells turned over rapidly and were replaced by the differentiation of proliferative stem cells' progeny in the intestinal crypts. This differentiation was blocked in the absence of ATOH1 -- a transcription factor required for the development of all intestinal secretory lineages. Yet tuft cell differentiation didn't require other transcription factors that specify enteroendocrine, Paneth, and goblet cells, suggesting that tuft cells represent a distinct lineage of intestinal secretory cells.

The team found that tuft cells secrete opioids and produce enzymes that synthesize prostaglandins. The latter observation suggests that tuft cells may promote inflammation and tumorigenesis. Indeed, the researchers identified tuft cell-like cells in several early stage intestinal tumors. To really understand tuft cells' function, however, Jay hopes to identify transcription factors uniquely required for their development in order to generate mice that specifically lack tuft cells from their intestinal epithelium.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gerbe, F., et al. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J. Cell Biol., vol. 192 no. 5 767-780 DOI: 10.1083/jcb.201010127

Cite This Page:

Rockefeller University Press. "New type of secretory cell in the intestine." ScienceDaily. ScienceDaily, 9 March 2011. <www.sciencedaily.com/releases/2011/03/110307124516.htm>.
Rockefeller University Press. (2011, March 9). New type of secretory cell in the intestine. ScienceDaily. Retrieved November 29, 2014 from www.sciencedaily.com/releases/2011/03/110307124516.htm
Rockefeller University Press. "New type of secretory cell in the intestine." ScienceDaily. www.sciencedaily.com/releases/2011/03/110307124516.htm (accessed November 29, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins