Featured Research

from universities, journals, and other organizations

One step closer to a diagnostic test for schizophrenia

Date:
April 6, 2011
Source:
Technical Research Centre of Finland (VTT)
Summary:
Scientists in Finland have revealed metabolic abnormalities that are associated with schizophrenia. This may be an important step towards development of a clinical test of the disease.

Scientists in Finland have revealed metabolic abnormalities that are associated with schizophrenia. This may be an important step towards development of a clinical test of the disease.

Schizophrenia is a chronic and severe psychotic disorder that affects around 1% of the population. Currently, there is no clinical test for diagnosing schizophrenia, and therefore the condition is usually recognized and treated on the basis of patient symptoms.

A new study performed by Matej Orešič and colleagues from VTT Technical Research Centre of Finland in collaboration with Jaana Suvisaari from the Finnish National Institute for Health and Welfare reveals metabolic abnormalities that are associated specifically with schizophrenia, as opposed to other psychotic disorders. These findings, which were published in Genome Medicine in March 2011, might be an important step towards the development of a clinical diagnostic test for schizophrenia.

The team used metabolomics, a high-throughput method for detecting small metabolites, to produce profiles of the serum metabolites associated with schizophrenia, other nonaffective psychosis (ONAP) or affective psychosis. Their analysis indicates that schizophrenia is associated with elevated serum levels of specific triglycerides, indicative of hyperinsulinemia, and also upregulation of the serum amino acid proline. Orešič et al. then combined these metabolic profiles to create a diagnostic model with the potential to discriminate schizophrenia from other psychoses.

This exciting study demonstrates how metabolomics can be a powerful tool for dissecting disease-related metabolic pathways and for identifying candidate diagnostic and prognostic markers in psychiatric research.


Story Source:

The above story is based on materials provided by Technical Research Centre of Finland (VTT). Note: Materials may be edited for content and length.


Journal Reference:

  1. Matej Oresic, Jing Tang, Tuulikki Seppanen-Laakso, Ismo Mattila, Suoma E Saarni, Samuli I Saarni, Jouko Lonnqvist, Marko Sysi-Aho, Tuulia Hyotylainen, Jonna Perala, Jaana Suvisaari. Metabolome in schizophrenia and other psychotic disorders: a general population-based study. Genome Medicine, 2011; 3 (3): 19 DOI: 10.1186/gm233

Cite This Page:

Technical Research Centre of Finland (VTT). "One step closer to a diagnostic test for schizophrenia." ScienceDaily. ScienceDaily, 6 April 2011. <www.sciencedaily.com/releases/2011/04/110405084302.htm>.
Technical Research Centre of Finland (VTT). (2011, April 6). One step closer to a diagnostic test for schizophrenia. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2011/04/110405084302.htm
Technical Research Centre of Finland (VTT). "One step closer to a diagnostic test for schizophrenia." ScienceDaily. www.sciencedaily.com/releases/2011/04/110405084302.htm (accessed August 20, 2014).

Share This




More Mind & Brain News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Charter Schools Alter Post-Katrina Landscape

Charter Schools Alter Post-Katrina Landscape

AP (Aug. 20, 2014) Nine years after Hurricane Katrina, charter schools are the new reality of public education in New Orleans. The state of Louisiana took over most of the city's public schools after the killer storm in 2005. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
Kids' Drawings At Age 4 Linked To Intelligence At Age 14

Kids' Drawings At Age 4 Linked To Intelligence At Age 14

Newsy (Aug. 19, 2014) A study by King's College London says there's a link between how well kids draw at age 4 and how intelligent they are later in life. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins