Featured Research

from universities, journals, and other organizations

Scientists develop a fatty 'kryptonite' to defeat multidrug-resistant 'super bugs'

Date:
June 17, 2011
Source:
Federation of American Societies for Experimental Biology
Summary:
"Super bugs," which can cause wide-spread disease and may be resistant to most, if not all, conventional antibiotics, still have their weaknesses. A team of Canadian scientists discovered that specific mixtures of antimicrobial agents presented in lipid (fatty) mixtures can significantly boost the effectiveness of those agents to kill the resistant bacteria.

Escherichia coli.
Credit: Tomasz Niewęgłowski / Fotolia

"Super bugs," which can cause wide-spread disease and may be resistant to most, if not all, conventional antibiotics, still have their weaknesses. A team of Canadian scientists discovered that specific mixtures of antimicrobial agents presented in lipid (fatty) mixtures can significantly boost the effectiveness of those agents to kill the resistant bacteria.

This discovery was published online in The FASEB Journal.

According to a researcher involved in the study, Richard Epand, Ph.D. from the Department of Biochemistry and Biomedical Science at McMaster University in Hamilton, Ontario, Canada, "This study may contribute to overcoming the lethal effects of drug resistant bacteria that is becoming an increasing clinical problem, particularly in hospitals."

To make their discovery, Epand and colleagues conducted experiments using groups of mice infected with lethal doses of multidrug-resistant Escherichia coli (E. coli). Researchers then treated the mice with conventional drug combinations or drug combinations encapsulated in lipid mixtures. They found that certain lipid mixtures caused the drugs to act together in a synergistic manner. In this form, the drugs were much more effective in increasing the survival rate of the mice because they overcame the cellular mechanisms used by these bacteria to defeat therapeutic agents.

This study also demonstrated a novel use of a new family of antimicrobial agents called oligo-acyl-lysyls, which have the potential to be combined with other drugs and lipid mixtures with similar properties to yield a platform for other specific applications.

"As we've seen in the recent E. coli outbreak in Germany, bacteria can mutate to become super bugs that resist antibiotics," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Thanks to this new, lipid-based antibiotic therapy, multidrug-resistant bacteria may begin to look more like Jimmy Olsen and a lot less like Superman."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. H. Sarig, D. Ohana, R. F. Epand, A. Mor, R. M. Epand. Functional studies of cochleate assemblies of an oligo-acyl-lysyl with lipid mixtures for combating bacterial multidrug resistance. The FASEB Journal, 2011; DOI: 10.1096/fj.11-183764

Cite This Page:

Federation of American Societies for Experimental Biology. "Scientists develop a fatty 'kryptonite' to defeat multidrug-resistant 'super bugs'." ScienceDaily. ScienceDaily, 17 June 2011. <www.sciencedaily.com/releases/2011/06/110616193740.htm>.
Federation of American Societies for Experimental Biology. (2011, June 17). Scientists develop a fatty 'kryptonite' to defeat multidrug-resistant 'super bugs'. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2011/06/110616193740.htm
Federation of American Societies for Experimental Biology. "Scientists develop a fatty 'kryptonite' to defeat multidrug-resistant 'super bugs'." ScienceDaily. www.sciencedaily.com/releases/2011/06/110616193740.htm (accessed October 21, 2014).

Share This



More Plants & Animals News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com
White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Traditional Farming Methods Gaining Ground in Mali

Traditional Farming Methods Gaining Ground in Mali

AFP (Oct. 20, 2014) He is leading a one man agricultural revolution in Mali - Oumar Diatabe uses traditional farming methods to get the most out of his land and is teaching others across the country how to do the same. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Goliath Spider Will Give You Nightmares

Goliath Spider Will Give You Nightmares

Buzz60 (Oct. 20, 2014) An entomologist stumbled upon a South American Goliath Birdeater. With a name like that, you know it's a terrifying creepy crawler. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins