Oct. 10, 2011 A possible new target for breast cancer therapy comes from the discovery that the Tyk2 protein helps suppress the growth and metastasis of breast tumors, as reported in Journal of Interferon & Cytokine Research, a peer-reviewed journal published by Mary Ann Liebert, Inc.
Qifang Zhang and Andrew Larner, Virginia Commonwealth University (Richmond, VA), and colleagues from VCU, Temple University School of Medicine (Philadelphia, PA), Jagiellonian University (Krakow, Poland), and Miyazaki University (Japan), present data demonstrating that mice lacking Tyk2 tyrosine kinase that are injected with breast cancer cells exhibit enhanced breast tumor growth and metastasis compared to mice with normal Tyk2 protein expression.
The authors conclude that altered Tyk2 expression affects the ability of the animals' immune systems to respond to the tumor challenge. They present the evidence in the article entitled, "The Role of Tyk2 in Regulation of Breast Cancer Growth," and they describe the role of Tyk2 in immunity-related biochemical signaling pathways.
"This study suggests that boosting Tyk2 activity may be beneficial for arresting breast tumor growth," says Ganes C. Sen, PhD, Chairman, Department of Molecular Genetics, Cleveland Clinic Foundation and Co-Editor-in-Chief of Journal of Interferon & Cytokine Research.
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- Qifang Zhang, Jamie L. Sturgill, Maciej Kmieciak, Karol Szczepanek, Marta Derecka, Catherine Koebel, Laura J. Graham, Yun Dai, Shuang Chen, Steven Grant, Joanna Cichy, Kazuya Shimoda, Ana Gamero, Masoud Manjili, Harry Bear, Daniel Conrad, Andrew C. Larner. The Role of Tyk2 in Regulation of Breast Cancer Growth. Journal of Interferon & Cytokine Research, 2011; 31 (9): 671 DOI: 10.1089/jir.2011.0023
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