In a discovery that may help speed use of "cell therapy" -- with normal cells or stem cells infused into the body to treat disease -- scientists are reporting development of a way to deliver therapeutic human cells to diseased areas within the body using a simple magnetic effect. Their report appears in ACS' journal Langmuir.
Rawil Fakhrullin and colleagues explain that cell therapy aims to replace damaged or diseased cells in the human body with normal cells or stem cells. To do so, medical personnel need a way to target these cells to diseased organs or tissues. So-called superparamagnetic iron oxide nanoparticles (SPIONs), attached to therapeutic cells, show promise. Magnetic devices could be used to move such cells to diseased areas of the body. But current ways of attaching SPIONs to therapeutic cells are difficult to use and may damage the therapeutic cells. So the researchers set out to develop a better process for attaching SPIONs to human cells.
They describe a new process for making "stabilized" SPIONs in the laboratory and successful attachment of these magnetic nanoparticles to the outside of human cells. They found that the SPIONs were not toxic to cells, and they moved in response to a magnet. "Our current results, as we believe, will inspire scientists to apply the simple and direct technique reported here in tissue engineering and cell-based therapies," say the researchers.
- Maria R. Dzamukova, Alsu I. Zamaleeva, Dilara G. Ishmuchametova, Yuri N. Osin, Andrey P. Kiyasov, Danis K. Nurgaliev, Olga N. Ilinskaya, Rawil F. Fakhrullin. A Direct Technique for Magnetic Functionalization of Living Human Cells. Langmuir, 2011; 27 (23): 14386 DOI: 10.1021/la203839v
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