Tumor-targeted bioluminescent bacteria have been shown for the first time to provide accurate 3-D images of tumors in mice, further advancing the potential for targeted cancer drug delivery, according to a study published in the Jan. 25 issue of the online journal PLoS ONE.
The specially engineered probiotic bacteria, like those found in many yogurts, were intravenously injected into mice with tumors, after which the researchers took full body bioluminescent images. The 3-D images revealed information about the number and location of the bacteria, to the level of precisely revealing where within the tumor the bacteria were living, providing much more information on the interaction of bacteria and tumors than was previously available using similar two-dimensional imaging methods.
According to the authors, led by Mark Tangney of University College Cork in Ireland, "before now, researchers used luminescence to provide an approximation of where a test organism was within the body, and would then follow up with multiple further experiments using different techniques to try to find a precise location."
This new research suggests that such bacteria can be engineered to contain diagnostic or therapeutic agents that would be produced specifically within the tumor for targeted treatment.
The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.
- Michelle Cronin, Ali R. Akin, Sara A. Collins, Jeff Meganck, Jae-Beom Kim, Chwanrow K. Baban, Susan A. Joyce, Gooitzen M. van Dam, Ning Zhang, Douwe van Sinderen, Gerald C. O'Sullivan, Noriyuki Kasahara, Cormac G. Gahan, Kevin P. Francis, Mark Tangney. High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting. PLoS ONE, 2012; 7 (1): e30940 DOI: 10.1371/journal.pone.0030940
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