Featured Research

from universities, journals, and other organizations

Overweight? New research explains how proper sleep is important for healthy weight

Date:
May 7, 2012
Source:
Federation of American Societies for Experimental Biology
Summary:
A new report shows that counting calories to lose weight is only part of the equation. Scientists show that impairments to a gene responsible for our internal body clocks, called "Rev-Erb alpha," leads to excessive weight gain and related health problems. This research provides insights into the importance of proper alignment between the body's internal timing and natural environmental light cycles to limit excessive weight gain and the problems weight gain causes.

If you're counting calories to lose weight, that may be only part of the weight loss equation says a new research report published online in The FASEB Journal. In the report, French scientists show that impairments to a gene known to be responsible for our internal body clocks, called "Rev-Erb alpha," leads to excessive weight gain and related health problems. This provides new insights into the importance of proper alignment between the body's internal timing and natural environmental light cycles to prevent or limit excessive weight gain and the problems this weight gain causes.

According to Etienne Challet, Ph.D., a researcher involved in the work from the Department of Neurobiology of Rhythms at the Institute of Cellular and Integrative Neurosciences at the University of Strasbourg in Pascal, France, "It is now clear that impairment of daily rhythms such as shift-work, exposure to artificial lighting, or jet-lag has multiple adverse effects on human health, every effort should be made to maintain or restore normal temporal organization and to avoid potentially disruptive behaviors such as nocturnal meals or light exposure at night."

To make this discovery, Challet and colleagues studied two groups of mice. One group was normal and the other group lacked the Rev-Erb alpha gene. In the mice lacking the Rev-Erb alpha gene, it was determined that they became obese and hyperglycaemic even if they ate the same quantity of food at the same time as normal mice. Further scientific investigation showed that when the Rev-Erb alpha-deficient mice were compared to the normal mice, there was a major difference in the way Rev-Erb alpha-deficient mice metabolized the food they ate. The Rev-Erb alpha deficient mice created much more fat than the normal mice, and this occurred specifically during the feeding period. Additionally, the Rev-Erb-alpha deficient mice relied less on carbohydrate stores when at rest.

"The phrase 'sick and tired' could never be more true," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This research shows that we evolved to live in synch with the natural light and dark cycles of our planet. Strasbourg has long taught us the finer aspects of cuisine; its scientists now explain how night and day can influence whether we are fat or lean."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Delezie, S. Dumont, H. Dardente, H. Oudart, A. Grechez-Cassiau, P. Klosen, M. Teboul, F. Delaunay, P. Pevet, E. Challet. The nuclear receptor REV-ERB is required for the daily balance of carbohydrate and lipid metabolism. The FASEB Journal, 2012; DOI: 10.1096/fj.12-208751

Cite This Page:

Federation of American Societies for Experimental Biology. "Overweight? New research explains how proper sleep is important for healthy weight." ScienceDaily. ScienceDaily, 7 May 2012. <www.sciencedaily.com/releases/2012/05/120507113734.htm>.
Federation of American Societies for Experimental Biology. (2012, May 7). Overweight? New research explains how proper sleep is important for healthy weight. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2012/05/120507113734.htm
Federation of American Societies for Experimental Biology. "Overweight? New research explains how proper sleep is important for healthy weight." ScienceDaily. www.sciencedaily.com/releases/2012/05/120507113734.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
U.S. Food Makers Surpass Calorie-Cutting Pledge

U.S. Food Makers Surpass Calorie-Cutting Pledge

Newsy (Sep. 18, 2014) Sixteen large food and beverage companies in the United States that committed to cut calories in their products far surpassed their target. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins