Featured Research

from universities, journals, and other organizations

Horse racing: Doping detection stays a neck ahead

Date:
August 8, 2012
Source:
IM Publications
Summary:
Whilst the eyes of the world may currently be focused on the Olympics, human sport is not the only area where drug testing is routinely carried out. Horse racing is a massive world-wide industry, and regular testing is essential to maintain its integrity. As with human sport, the authorities constantly need to develop methodologies to detect new compounds that drug cheats are using or may start to use. One such compound is peginesatide.

Horse racing is a massive world-wide industry, and regular testing is essential to maintain its integrity.
Credit: © timjrye / Fotolia

Whilst the eyes of the world may currently be focused on the Olympics, human sport is not the only area where drug testing is routinely carried out. Horse racing is a massive world-wide industry, and regular testing is essential to maintain its integrity. As with human sport, the authorities constantly need to develop methodologies to detect new compounds that drug cheats are using or may start to use. One such compound is peginesatide.

Peginesatide is the first representative of a new class of compounds that mimic the effects of erythropoietin; these include an increase in the number of red blood cells and of haemoglobin levels in the blood. Both of these increase endurance and so-called erythropoiesis-stimulating agents (ESAs) are banned in human and equine sports.

The approval of the use of peginesatide by the US Food and Drug Administration (FDA) to treat anemia in patients on dialysis increases its availability and the chance of its use in illegal performance enhancement.

A new mass spectrometry method for detecting peginesatide in humans has already been developed, and now the extension of this for the detection of peginesatide in horse serum is described in an article published in EJMS -- European Journal of Mass Spectrometry written by Ines Möller, Andreas Thomas, Anke Wingender, Marc Machnik, Wilhelm Schänzer and Mario Thevis from the German Sport University Cologne, Germany. This is timely since the German Equestrian Federation has recently added peginesatide to its prohibited substance list.

The new method uses electrospray ionisation (ESI) liquid chromatography-tandem mass spectrometry (LC-MS/MS). Samples are prepared using the serine endopeptidase subtilisin to break down the compounds in the sample prior to LC-MS/MS analysis.

According to lead author Mario Thevis, "The method is precise, specific and linear over a wide concentration range. Further, being simple, fast, cost effective, easily transferable to other laboratories and in accordance with the criteria for 'identification by chromatography and mass spectrometry' outlined by the Association of Official Racing Chemists (AORC), the method is suitable for routine use in the horse sports drug testing arena."


Story Source:

The above story is based on materials provided by IM Publications. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ines Möller, Andreas Thomas, Anke Wingender, Marc Machnik, Wilhelm Schänzer, Mario Thevis. Detection of peginesatide in equine serum using liquid chromatography-tandem mass spectrometry for doping control purposes. European Journal of Mass Spectrometry, 2011; DOI: 10.1255/ejms.1189

Cite This Page:

IM Publications. "Horse racing: Doping detection stays a neck ahead." ScienceDaily. ScienceDaily, 8 August 2012. <www.sciencedaily.com/releases/2012/08/120808132528.htm>.
IM Publications. (2012, August 8). Horse racing: Doping detection stays a neck ahead. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2012/08/120808132528.htm
IM Publications. "Horse racing: Doping detection stays a neck ahead." ScienceDaily. www.sciencedaily.com/releases/2012/08/120808132528.htm (accessed September 17, 2014).

Share This



More Plants & Animals News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Tobacco Farmers Thrive Amid Challenges

Some Tobacco Farmers Thrive Amid Challenges

AP (Sep. 16, 2014) — The South's tobacco country is surviving, and even thriving in some cases, as demand overseas keeps growers in the fields of one of America's oldest cash crops. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

AFP (Sep. 16, 2014) — Scientists say a female colossal squid weighing an estimated 350 kilograms (770 lbs) and thought to be only the second intact specimen ever found was carrying eggs when discovered in the Antarctic. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Raw: Scientists Examine Colossal Squid

Raw: Scientists Examine Colossal Squid

AP (Sep. 16, 2014) — Squid experts in New Zealand thawed and examined an unusual catch on Tuesday: a colossal squid. It was captured in Antarctica's remote Ross Sea in December last year and has been frozen for eight months. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) — Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins