Featured Research

from universities, journals, and other organizations

Horse racing: Doping detection stays a neck ahead

Date:
August 8, 2012
Source:
IM Publications
Summary:
Whilst the eyes of the world may currently be focused on the Olympics, human sport is not the only area where drug testing is routinely carried out. Horse racing is a massive world-wide industry, and regular testing is essential to maintain its integrity. As with human sport, the authorities constantly need to develop methodologies to detect new compounds that drug cheats are using or may start to use. One such compound is peginesatide.

Horse racing is a massive world-wide industry, and regular testing is essential to maintain its integrity.
Credit: © timjrye / Fotolia

Whilst the eyes of the world may currently be focused on the Olympics, human sport is not the only area where drug testing is routinely carried out. Horse racing is a massive world-wide industry, and regular testing is essential to maintain its integrity. As with human sport, the authorities constantly need to develop methodologies to detect new compounds that drug cheats are using or may start to use. One such compound is peginesatide.

Related Articles


Peginesatide is the first representative of a new class of compounds that mimic the effects of erythropoietin; these include an increase in the number of red blood cells and of haemoglobin levels in the blood. Both of these increase endurance and so-called erythropoiesis-stimulating agents (ESAs) are banned in human and equine sports.

The approval of the use of peginesatide by the US Food and Drug Administration (FDA) to treat anemia in patients on dialysis increases its availability and the chance of its use in illegal performance enhancement.

A new mass spectrometry method for detecting peginesatide in humans has already been developed, and now the extension of this for the detection of peginesatide in horse serum is described in an article published in EJMS -- European Journal of Mass Spectrometry written by Ines Möller, Andreas Thomas, Anke Wingender, Marc Machnik, Wilhelm Schänzer and Mario Thevis from the German Sport University Cologne, Germany. This is timely since the German Equestrian Federation has recently added peginesatide to its prohibited substance list.

The new method uses electrospray ionisation (ESI) liquid chromatography-tandem mass spectrometry (LC-MS/MS). Samples are prepared using the serine endopeptidase subtilisin to break down the compounds in the sample prior to LC-MS/MS analysis.

According to lead author Mario Thevis, "The method is precise, specific and linear over a wide concentration range. Further, being simple, fast, cost effective, easily transferable to other laboratories and in accordance with the criteria for 'identification by chromatography and mass spectrometry' outlined by the Association of Official Racing Chemists (AORC), the method is suitable for routine use in the horse sports drug testing arena."


Story Source:

The above story is based on materials provided by IM Publications. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ines Möller, Andreas Thomas, Anke Wingender, Marc Machnik, Wilhelm Schänzer, Mario Thevis. Detection of peginesatide in equine serum using liquid chromatography-tandem mass spectrometry for doping control purposes. European Journal of Mass Spectrometry, 2011; DOI: 10.1255/ejms.1189

Cite This Page:

IM Publications. "Horse racing: Doping detection stays a neck ahead." ScienceDaily. ScienceDaily, 8 August 2012. <www.sciencedaily.com/releases/2012/08/120808132528.htm>.
IM Publications. (2012, August 8). Horse racing: Doping detection stays a neck ahead. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2012/08/120808132528.htm
IM Publications. "Horse racing: Doping detection stays a neck ahead." ScienceDaily. www.sciencedaily.com/releases/2012/08/120808132528.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gorilla Falls Into Zoo Moat

Gorilla Falls Into Zoo Moat

Reuters - Light News Video Online (Mar. 31, 2015) — A gorilla comes to the rescue of her sister who fell into a moat in Israel&apos;s Safari zoo. Rough cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Giant Amphibian Fossils Found in Portugal

Giant Amphibian Fossils Found in Portugal

Reuters - Light News Video Online (Mar. 31, 2015) — Scientists discover a new species of giant amphibian that was one of the largest predators on earth about 220 million year ago. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Rhino Goes on Deadly Rampage in Nepal

Rhino Goes on Deadly Rampage in Nepal

Reuters - News Video Online (Mar. 31, 2015) — A rhino runs rampant down a bustling city street, killing one woman and injuring several others, before security personnel chase it back into the forest. Vanessa Johnston reports. Video provided by Reuters
Powered by NewsLook.com
Bionic Ants Could Be Tomorrow's Factory Workers

Bionic Ants Could Be Tomorrow's Factory Workers

Reuters - Innovations Video Online (Mar. 30, 2015) — Industrious 3D printed bionic ants working together could toil in the factories of the future, says German technology company Festo. The robotic insects cooperate and coordinate their actions and movements to achieve a common aim. Amy Pollock reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins