Featured Research

from universities, journals, and other organizations

Bacterial protein in house dust spurs asthma, study finds

Date:
October 15, 2012
Source:
National Institute of Environmental Health Sciences (NIEHS)
Summary:
A bacterial protein in common house dust may worsen allergic responses to indoor allergens, according to new research. The finding is the first to document the presence of the protein flagellin in house dust, bolstering the link between allergic asthma and the environment.

A bacterial protein in common house dust may worsen allergic responses to indoor allergens, according to research conducted by the National Institutes of Health and Duke University. The finding is the first to document the presence of the protein flagellin in house dust, bolstering the link between allergic asthma and the environment.

Related Articles


Scientists from the NIH's National Institute of Environmental Health Sciences (NIEHS) and Duke University Medical Center published their findings in people and mice online Oct. 14 in the journal Nature Medicine.

"Most people with asthma have allergic asthma, resulting largely from allergic responses to inhaled substances," said the paper's corresponding author Donald Cook, Ph.D., an NIEHS scientist. His research team began the study to identify environmental factors that amplify the allergic responses. "Although flagellin is not an allergen, it can boost allergic responses to true allergens."

After inhaling house dust, mice that were able to respond to flagellin displayed all of the common symptoms of allergic asthma, including more mucous production, airway obstruction, and airway inflammation. However, mice lacking a gene that detects the presence of flagellin had reduced levels of these symptoms.

"More work will be required to confirm our conclusions, but it's possible that cleaning can reduce the amount of house dust in general, and flagellated bacteria in particular, to reduce the incidence of allergic asthma," Cook said.

In addition to the mouse study, the research team also determined that people with asthma have higher levels of antibodies against flagellin in their blood than do non-asthmatic subjects, which provides more evidence of a link between environmental factors and allergic asthma in humans.

"More than 20 million Americans have asthma, with 4,000 deaths from the disease occurring each year," added Darryl Zeldin, M.D., NIEHS scientific director and paper co-author. "All of these data suggest that flagellin in common house dust can promote allergic asthma by priming allergic responses to common indoor allergens."


Story Source:

The above story is based on materials provided by National Institute of Environmental Health Sciences (NIEHS). Note: Materials may be edited for content and length.


Journal Reference:

  1. Rhonda H Wilson, Shuichiro Maruoka, Gregory S Whitehead, Julie F Foley, Gordon P Flake, Michelle L Sever, Darryl C Zeldin, Monica Kraft, Stavros Garantziotis, Hideki Nakano, Donald N Cook. The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens. Nature Medicine, 2012; DOI: 10.1038/nm.2920

Cite This Page:

National Institute of Environmental Health Sciences (NIEHS). "Bacterial protein in house dust spurs asthma, study finds." ScienceDaily. ScienceDaily, 15 October 2012. <www.sciencedaily.com/releases/2012/10/121015121740.htm>.
National Institute of Environmental Health Sciences (NIEHS). (2012, October 15). Bacterial protein in house dust spurs asthma, study finds. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2012/10/121015121740.htm
National Institute of Environmental Health Sciences (NIEHS). "Bacterial protein in house dust spurs asthma, study finds." ScienceDaily. www.sciencedaily.com/releases/2012/10/121015121740.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins