Featured Research

from universities, journals, and other organizations

Bacterial protein in house dust spurs asthma, study finds

Date:
October 15, 2012
Source:
National Institute of Environmental Health Sciences (NIEHS)
Summary:
A bacterial protein in common house dust may worsen allergic responses to indoor allergens, according to new research. The finding is the first to document the presence of the protein flagellin in house dust, bolstering the link between allergic asthma and the environment.

A bacterial protein in common house dust may worsen allergic responses to indoor allergens, according to research conducted by the National Institutes of Health and Duke University. The finding is the first to document the presence of the protein flagellin in house dust, bolstering the link between allergic asthma and the environment.

Related Articles


Scientists from the NIH's National Institute of Environmental Health Sciences (NIEHS) and Duke University Medical Center published their findings in people and mice online Oct. 14 in the journal Nature Medicine.

"Most people with asthma have allergic asthma, resulting largely from allergic responses to inhaled substances," said the paper's corresponding author Donald Cook, Ph.D., an NIEHS scientist. His research team began the study to identify environmental factors that amplify the allergic responses. "Although flagellin is not an allergen, it can boost allergic responses to true allergens."

After inhaling house dust, mice that were able to respond to flagellin displayed all of the common symptoms of allergic asthma, including more mucous production, airway obstruction, and airway inflammation. However, mice lacking a gene that detects the presence of flagellin had reduced levels of these symptoms.

"More work will be required to confirm our conclusions, but it's possible that cleaning can reduce the amount of house dust in general, and flagellated bacteria in particular, to reduce the incidence of allergic asthma," Cook said.

In addition to the mouse study, the research team also determined that people with asthma have higher levels of antibodies against flagellin in their blood than do non-asthmatic subjects, which provides more evidence of a link between environmental factors and allergic asthma in humans.

"More than 20 million Americans have asthma, with 4,000 deaths from the disease occurring each year," added Darryl Zeldin, M.D., NIEHS scientific director and paper co-author. "All of these data suggest that flagellin in common house dust can promote allergic asthma by priming allergic responses to common indoor allergens."


Story Source:

The above story is based on materials provided by National Institute of Environmental Health Sciences (NIEHS). Note: Materials may be edited for content and length.


Journal Reference:

  1. Rhonda H Wilson, Shuichiro Maruoka, Gregory S Whitehead, Julie F Foley, Gordon P Flake, Michelle L Sever, Darryl C Zeldin, Monica Kraft, Stavros Garantziotis, Hideki Nakano, Donald N Cook. The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens. Nature Medicine, 2012; DOI: 10.1038/nm.2920

Cite This Page:

National Institute of Environmental Health Sciences (NIEHS). "Bacterial protein in house dust spurs asthma, study finds." ScienceDaily. ScienceDaily, 15 October 2012. <www.sciencedaily.com/releases/2012/10/121015121740.htm>.
National Institute of Environmental Health Sciences (NIEHS). (2012, October 15). Bacterial protein in house dust spurs asthma, study finds. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2012/10/121015121740.htm
National Institute of Environmental Health Sciences (NIEHS). "Bacterial protein in house dust spurs asthma, study finds." ScienceDaily. www.sciencedaily.com/releases/2012/10/121015121740.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
London Show Dissects History of Forensic Science

London Show Dissects History of Forensic Science

AFP (Feb. 25, 2015) Forensic science, which has fascinated generations with its unravelling of gruesome crime mysteries, is being put under the microscope in an exhibition of real criminal investigations in London. Duration: 00:53 Video provided by AFP
Powered by NewsLook.com
Michigan Couple Celebrates Identical Triplets

Michigan Couple Celebrates Identical Triplets

AP (Feb. 25, 2015) A suburban Detroit couple who have two older children are adjusting to life after becoming parents to identical triplets _ a multiple birth a doctor calls rare. (Feb. 25) Video provided by AP
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins