Featured Research

from universities, journals, and other organizations

Medicinal 'toothbrush tree' yields antibiotic to treat TB in new way

Date:
January 14, 2013
Source:
Norwich BioScience Institutes
Summary:
There are potentially new TB drugs in the pipeline from unusual sources. A newly discovered compound has been found to be effective against resistant strains of TB.

A compound from the South African toothbrush tree inactivates a drug target for tuberculosis in a previously unseen way. Tuberculosis causes more deaths worldwide than any other bacterial disease. At the same time as rates are increasing, resistance strains are emerging due, in part, to non-compliance with the treatment required. Many current drugs are nearly 50 years old and alternatives are needed to the long, demanding treatment schedules.

The compound under research, diospyrin, binds to a novel site on a well-known enzyme, called DNA gyrase, and inactivates the enzyme. DNA gyrase is essential for bacteria and plants but is not present in animals or humans. It is established as an effective and safe drug target for antibiotics.

"The way that diospyrin works helps to explain why it is effective against drug-sensitive and drug-resistant strains of tuberculosis," said Professor Tony Maxwell from the John Innes Centre.

In traditional medicine the antibacterial properties of the tree are used for oral health and to treat medical complaints such bronchitis, pleurisy and venereal disease. Twigs from the tree are traditionally used as toothbrushes.

Most antibiotics originate from naturals sources, such as the soil bacteria Streptomyces. Antibiotics derived from plants are less common, but they are potentially rich sources of new medicines.

"Extracts from plants used in traditional medicine provide a source for novel compounds that may have antibacterial properties, which may then be developed as antibiotics," said Professor Maxwell.

"This highlights the value of ethnobotany and the value of maintaining biodiversity to help us address global problems."

The work on diospyrin and related naphthoquinone compounds is being continued by Professor Maxwell as part of the efforts of a consortium of European researchers, More Medicines For Tuberculosis (MM4TB). The collaboration between 25 labs across Europe is dedicated to the development of new drugs for TB.


Story Source:

The above story is based on materials provided by Norwich BioScience Institutes. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Karkare, T. T. H. Chung, F. Collin, L. A. Mitchenall, A. R. McKay, S. J. Greive, J. J. M. Meyer, N. Lall, A. Maxwell. The Naphthoquinone Diospyrin is an Inhibitor of DNA Gyrase with a Novel Mechanism of Action. Journal of Biological Chemistry, 2012; DOI: 10.1074/jbc.M112.419069

Cite This Page:

Norwich BioScience Institutes. "Medicinal 'toothbrush tree' yields antibiotic to treat TB in new way." ScienceDaily. ScienceDaily, 14 January 2013. <www.sciencedaily.com/releases/2013/01/130114092755.htm>.
Norwich BioScience Institutes. (2013, January 14). Medicinal 'toothbrush tree' yields antibiotic to treat TB in new way. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2013/01/130114092755.htm
Norwich BioScience Institutes. "Medicinal 'toothbrush tree' yields antibiotic to treat TB in new way." ScienceDaily. www.sciencedaily.com/releases/2013/01/130114092755.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins