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Exposure to pesticides in food, air and water increases risk of type 2 diabetes, study finds

Date:
February 5, 2013
Source:
University of Granada
Summary:
A study led by researchers in Spain reveals that there is a direct relationship between the presence of persistent organic pollutants in the body and the development of type 2 diabetes, regardless of the patient's age, gender or body mass index.
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From left to right, some of the researchers at the University of Granada laboratory: Juan Pedro Arrebola, Francisco Artacho and María Fernández.
Credit: Image courtesy of University of Granada

A study led by the University of Granada reveals that there is a direct relationship between the presence of Persistent Organic Pollutants in the body and the development of type 2 diabetes, regardless of the patient's age, gender or body mass index.

A study conducted at the University of Granada has revealed that there is a direct relationship between exposure to pesticides (Persistent Organic Pollutants, CPOs) in food, air and water and prevalence of type 2 diabetes in adults, regardless of age, gender and body mass index. These substances tend to concentrate in body fat, and they might be one of the reasons why obese people are more likely to develop diabetes, since the more fat the higher the COP concentrations in the body.

In a paper recently published in the journal Environmental Research, researchers demonstrate that people with higher concentrations of DDE -the main metabolite in the pesticide DDT- are four times more likely to develop type 2 diabetes than other people. In addition, the risk of type 2 diabetes is also associated with exposure to β-HCH (beta-Hexachlorocyclohexane), which is present in the formula of the pesticide Lindano.

A Study with 386 Subjects

To carry out this study, the researchers analyzed the concentrations of a specific group of COPs in the adipose tissue of 386 adult subjects assisted at San Cecilio hospital, Granada, and Santa Ana hospital, Motril, Spain. According to the University of Granada and San Cecilio researcher, Juan Pedro Arrebola, "human adipose tissue (commonly known as "fat") acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as persistent organic pollutants (COPs)."

This makes COPs concentrations a useful marker of a subject's exposure to COPs. COPs are a group of chemicals with diverse characteristics which are present in pesticides, industrial waste and building materials. These compounds penetrate the body mainly through food, but also through air or the skin.

According to professor Arrebola, "the mechanism of action by which COPs increases the risk of diabetes is still unknown. However, some researchers have suggested that COPs might cause an immunological response when they penetrate estrogen receptors in tissues associated with the metabolism of sugars."

The prevalence of diabetes in the world has significantly increased in the last decades. It is estimated that by 2030, 4.4% of the world population have this metabolic disorder. This will have a severe impact on public health programs, since it is highly resource-consuming. The factors causing such increase in the prevalence of diabetes are not still clearly understood.

This research study was conducted by researchers at San Cecilio University Hospital, Granada, the University of Granada and the Andalusian School of Public Health, Santa Ana hospital, Motril, and the Hospital del Mar d'Investigacions Mèdiques, Barcelona. According to the authors of the study "we are an example of clinical research focused on common diseases with a high impact on health."


Story Source:

The above story is based on materials provided by University of Granada. Note: Materials may be edited for content and length.


Journal Reference:

  1. Juan P. Arrebola, José Pumarega, Magda Gasull, Mariana F. Fernandez, Piedad Martin-Olmedo, José M. Molina-Molina, María Fernández-Rodríguez, Miquel Porta, Nicolás Olea. Adipose tissue concentrations of persistent organic pollutants and prevalence of type 2 diabetes in adults from Southern Spain. Environmental Research, 2013; DOI: 10.1016/j.envres.2012.12.001

Cite This Page:

University of Granada. "Exposure to pesticides in food, air and water increases risk of type 2 diabetes, study finds." ScienceDaily. ScienceDaily, 5 February 2013. <www.sciencedaily.com/releases/2013/02/130205101415.htm>.
University of Granada. (2013, February 5). Exposure to pesticides in food, air and water increases risk of type 2 diabetes, study finds. ScienceDaily. Retrieved May 27, 2015 from www.sciencedaily.com/releases/2013/02/130205101415.htm
University of Granada. "Exposure to pesticides in food, air and water increases risk of type 2 diabetes, study finds." ScienceDaily. www.sciencedaily.com/releases/2013/02/130205101415.htm (accessed May 27, 2015).

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