Featured Research

from universities, journals, and other organizations

Newt transcriptome offers insight into tissue regeneration

Date:
February 20, 2013
Source:
BioMed Central Limited
Summary:
Scientists have identified protein families expressed during tissue regeneration in newts, providing the groundwork for research into whether particular sets of genes are used for the purpose.

Scientists have identified protein families expressed during tissue regeneration in newts, providing the groundwork for research into whether particular sets of genes are used for the purpose. The transcriptome -- the map of all RNA molecules -- of the newt is published this week in BioMed Central’s open access journal Genome Biology.
Credit: Thomas Braun

Scientists have identified protein families expressed during tissue regeneration in newts, providing the groundwork for research into whether particular sets of genes are used for the purpose. The transcriptome -- the map of all RNA molecules -- of the newt is published this week in BioMed Central's open access journal Genome Biology. Notophthalmus viridescens is a useful model in regenerative medicine, thanks to its ability to regenerate tissue, and this data gives insights into the mechanisms behind this process.

N. viridescens, the common newt, is native to North America, and an urodelian amphibian. Newt and salamander genomes are enormous; currently too big to sequence, but their potential to regenerate entire limbs, along with parts of the central nervous system, has fascinated scientists for over 200 years. Thomas Braun, Thilo Borchardt at the Max Planck Institutes, Patagonis Tsonis at the University of Dayton and their colleagues sequenced a collection of healthy and regenerated tissues from newts, and converged them into one comprehensive transcriptome. Their analysis identified 826 proteins specific for urodeles, and several newly identified proteins that they believe may play important roles in regeneration process unique for urodeles. Their data also outline genes that appear only in regenerating, but not uninjured material, which will be of interest in regenerative medicine.

The transcriptome is not complete, but serves as a matrix for further analyses. The authors believe that their findings represent only the tip of the iceberg: 'Our data provide the groundwork for mechanistic experiments to answer the question whether urodeles utilize proprietary sets of genes for tissue regeneration.' They continue: 'The newly established de novo transcriptome [...] will be an indispensable resource for a better understanding of regenerative events in newts and facilitate the identifications of molecules [...] that control this fascinating process.'


Story Source:

The above story is based on materials provided by BioMed Central Limited. Note: Materials may be edited for content and length.


Journal Reference:

  1. mario Looso, Jens Preussner, Konstantinos Sousounis, Marc Bruckskotten, Christian S. Michel, Ettore Lignelli, Richard Reinhardt, Sabrina Hφffner, Marcus Krόger, Panagiotis A. Tsonis, Thilo Borchardt and Thomas Braun. A de novo assembly of the newt transcriptome combined with proteomic validation identifies new protein families expressed during tissue regeneration. Genome Biology, 2013; (in press) [link]

Cite This Page:

BioMed Central Limited. "Newt transcriptome offers insight into tissue regeneration." ScienceDaily. ScienceDaily, 20 February 2013. <www.sciencedaily.com/releases/2013/02/130219201525.htm>.
BioMed Central Limited. (2013, February 20). Newt transcriptome offers insight into tissue regeneration. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2013/02/130219201525.htm
BioMed Central Limited. "Newt transcriptome offers insight into tissue regeneration." ScienceDaily. www.sciencedaily.com/releases/2013/02/130219201525.htm (accessed September 3, 2014).

Share This



More Health & Medicine News

Wednesday, September 3, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) — You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) — The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) — As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) — When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins