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Biting back: Snake venom contains toxic clotting factors

Date:
February 27, 2013
Source:
BioMed Central Limited
Summary:
The powerful venom of the saw-scaled viper Echis carinatus contains both anticoagulants and coagulants according to a new study. These may be a source of potent drugs to treat human disease. The saw-scaled viper family Echis, responsible for most snake attacks on humans, are recognizable by the ‘sizzling’ noise they make, produced by rubbing together special serrated scales, when threatened. Echis venom causes coagulopathy, which can result in symptoms ranging from lack of blood clotting, hemorrhage, renal failure and stroke.

The powerful venom of the saw-scaled viper Echis carinatus contains both anticoagulants and coagulants finds a study published in the launch edition of BioMed Central's open access journal Journal of Venomous Animals and Toxins including Tropical Diseases (JVATiTD). These may be a source of potent drugs to treat human disease.

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The saw-scaled viper family Echis, responsible for most snake attacks on humans, are recognizable by the 'sizzling' noise they make, produced by rubbing together special serrated scales, when threatened. Echis venom causes coagulopathy, which can result in symptoms ranging from lack of blood clotting, hemorrhage, renal failure and stroke.

Researchers from the Razi Vaccine and Serum Research Institute, Iran led by Hossein Zolfagharian noted that treating plasma with venom from Echis carinatus actually causes it to coagulate. Splitting the venom by ion exchange chromatography showed that then venom contained both coagulants and anticoagulants. The clotting factors alone were toxic to mice.

The diametric effects of snake venom on blood are of interest because of medical applications, and although snakes can be considered as dangerous to humans -- they may yet save lives.

In the auspicious Year of the Snake, BioMed Central, the open access publisher, is pleased to announce that the Journal of Venomous Animals and Toxins including Tropical Diseases (JVATiTD), the official academic journal of the The Center for the Study of Venoms and Venomous Animals (CEVAP) of São Paulo State University (UNESP), based in Brazil, has moved to BioMed Central's open access publishing platform. Also this journal marks growth of BioMed Central's portfolio of open access journals to 250.

Along with research into snakes JVATiTD publishes studies into all aspects of toxins, venomous animals, and their derivative products, as well as tropical diseases especially infectious diseases, parasites and immunology.


Story Source:

The above story is based on materials provided by BioMed Central Limited. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hossein Salmanizadeh, Mahdi Babaie and Hossein Zolfagharian. In vivo evaluation of homeostatic effects of Echis carinatus snake venom in Iran. Journal of Venomous Animals and Toxins including Tropical Diseases, 2013, 19:3 DOI: 10.1186/1678-9199-19-3

Cite This Page:

BioMed Central Limited. "Biting back: Snake venom contains toxic clotting factors." ScienceDaily. ScienceDaily, 27 February 2013. <www.sciencedaily.com/releases/2013/02/130226193845.htm>.
BioMed Central Limited. (2013, February 27). Biting back: Snake venom contains toxic clotting factors. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2013/02/130226193845.htm
BioMed Central Limited. "Biting back: Snake venom contains toxic clotting factors." ScienceDaily. www.sciencedaily.com/releases/2013/02/130226193845.htm (accessed December 19, 2014).

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