Featured Research

from universities, journals, and other organizations

Scientists throw new light on DNA copying process

Date:
April 18, 2013
Source:
University of York
Summary:
Scientists have thrown new light on the way breakdowns in the DNA copying process inside cells can contribute to cancer and other diseases.

The project focused on a bacterium called Escherichia coli which is a powerful model for studying the DNA copying process, the study of which has revealed many aspects of DNA metabolism in more complex organisms such as humans.
Credit: Image courtesy of University of York

Research led by a scientist at the University of York has thrown new light on the way breakdowns in the DNA copying process inside cells can contribute to cancer and other diseases.

Peter McGlynn, an Anniversary Professor in the University's Department of Biology, led a team of researchers who have discovered that the protein machines that copy DNA in a model organism pause frequently during this copying process, creating the potential for dangerous mutations to develop.

The research, which is published in the Proceedings of the National Academy of Sciences (PNAS), involved scientists at the School of Medical Sciences at the University of Aberdeen, where Professor McGlynn worked previously, the Centre for Genetics and Genomics at the Queen's Medical Centre, University of Nottingham and the Memorial Sloan-Kettering Cancer Center, New York.

The project focused on a bacterium called Escherichia coli which is a powerful model for studying the DNA copying process, the study of which has revealed many aspects of DNA metabolism in more complex organisms such as humans.

Professor McGlynn, who was one of 16 Chairs established at York to mark the University's 50th Anniversary, says: "Our work demonstrates that when organisms try to copy their genetic material, the copying machines stall very frequently which is the first step in formation of mutations that, in man, can cause cancers and genetic disease.

"We have analysed what causes most of these breakdowns and how, under normal circumstances, cells repair these broken copying machines. Just as importantly, our work reveals that efficient repair of these breakdowns is very important to avoid corruption of the genetic code."

The research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC).


Story Source:

The above story is based on materials provided by University of York. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. K. Gupta, C. P. Guy, J. T. P. Yeeles, J. Atkinson, H. Bell, R. G. Lloyd, K. J. Marians, P. McGlynn. Protein-DNA complexes are the primary sources of replication fork pausing in Escherichia coli. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1303890110

Cite This Page:

University of York. "Scientists throw new light on DNA copying process." ScienceDaily. ScienceDaily, 18 April 2013. <www.sciencedaily.com/releases/2013/04/130418104334.htm>.
University of York. (2013, April 18). Scientists throw new light on DNA copying process. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2013/04/130418104334.htm
University of York. "Scientists throw new light on DNA copying process." ScienceDaily. www.sciencedaily.com/releases/2013/04/130418104334.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins