Featured Research

from universities, journals, and other organizations

Probing the secrets of the ryegrasses: A route for synthesis of loline alkaloids

Date:
October 1, 2013
Source:
Ludwig-Maximilians-Universitaet Muenchen (LMU)
Summary:
Loline alkaloids protect plants from attack by insects and have other interesting features that have yet to be studied in detail. Chemists have developed a method for the effective synthesis of these compounds, which will facilitate further investigations in biology and medicine.

Loline alkaloids protect plants from attack by insects and have other interesting features that have yet to be studied in detail. Chemists from Ludwig-Maximilians-Universitaet in Munich have developed a method for the effective synthesis of these compounds, which will facilitate further investigations in biology and medicine.

Related Articles


Chemists from Ludwig-Maximilians-Universitaet in Munich led by Professor Dirk Trauner have developed a concise and efficient method for the synthesis of the alkaloid loline and related compounds.

Loline alkaloids are a biologically interesting group of natural products, which have unusual physicochemical and pharmacological characteristics, but are as of yet poorly understood. They are produced by fungal symbionts that infect weeds and forage grasses, and act as deterrents of insects and other herbivores.

Some of the agents synthesized by endophytic fungi are toxic to grazing animals, producing a syndrome known as the staggers. Indeed, such toxic weeds (commonly called ryegrass or cockle) were much feared in antiquity and are mentioned both by Virgil and in the New Testament.

Lolines however are comparatively innocuous to mammalian herbivores, and might therefore be of some therapeutic use. The loline alkaloid temuline has attracted particular attention in another context because it can strongly bind carbon dioxide.

Lolines are relatively small molecules and have a fairly simple structure, but chemical synthesis of the compounds has proven to be quite challenging. "Our synthetic route is highly efficient and, with a maximum of 10 steps, very short," says Dirk Trauner, who led the project. "It will allow us to make these compounds in sufficient quantities to enable their various aspects to be investigated in detail. We should then be able to dissect the complex network of interactions of the plants and their fungal parasites with insects and bacteria. We now plan to use our synthetic material to identify the receptor for loline alkaloids."


Story Source:

The above story is based on materials provided by Ludwig-Maximilians-Universitaet Muenchen (LMU). Note: Materials may be edited for content and length.


Cite This Page:

Ludwig-Maximilians-Universitaet Muenchen (LMU). "Probing the secrets of the ryegrasses: A route for synthesis of loline alkaloids." ScienceDaily. ScienceDaily, 1 October 2013. <www.sciencedaily.com/releases/2013/10/131001131209.htm>.
Ludwig-Maximilians-Universitaet Muenchen (LMU). (2013, October 1). Probing the secrets of the ryegrasses: A route for synthesis of loline alkaloids. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2013/10/131001131209.htm
Ludwig-Maximilians-Universitaet Muenchen (LMU). "Probing the secrets of the ryegrasses: A route for synthesis of loline alkaloids." ScienceDaily. www.sciencedaily.com/releases/2013/10/131001131209.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Matter & Energy News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Who Will Failed Nuclear Talks Hurt Most?

Who Will Failed Nuclear Talks Hurt Most?

Reuters - Business Video Online (Nov. 25, 2014) With no immediate prospect of sanctions relief for Iran, and no solid progress in negotiations with the West over the country's nuclear programme, Ciara Lee asks why talks have still not produced results and what a resolution would mean for both parties. Video provided by Reuters
Powered by NewsLook.com
Flying Enthusiast Converts Real-Life Aircraft Cockpit Into Simulator

Flying Enthusiast Converts Real-Life Aircraft Cockpit Into Simulator

Reuters - Innovations Video Online (Nov. 25, 2014) A virtual flying enthusiast converts parts of a written-off Airbus aircraft into a working flight simulator in his northern Slovenian home. Jim Drury reports. Video provided by Reuters
Powered by NewsLook.com
Car Park Solution for Flexible Green Energy

Car Park Solution for Flexible Green Energy

Reuters - Innovations Video Online (Nov. 24, 2014) A British solar power start-up says that by covering millions of existing car park spaces around the UK with flexible solar panels, the country's power problems could be solved. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Microsoft Adds Robot Guards, Ushers In Sci-Fi Apocalypse

Microsoft Adds Robot Guards, Ushers In Sci-Fi Apocalypse

Newsy (Nov. 23, 2014) Microsoft has robotic security guards working at its Silicon Valley Campus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins