Featured Research

from universities, journals, and other organizations

Sugar intake not directly related to liver disease

Date:
November 1, 2013
Source:
American Gastroenterological Association
Summary:
Despite current beliefs, sugar intake is not directly associated with nonalcoholic fatty liver disease, according to a new study. Rather, high-calorie diets promote the progression of this serious form of liver disease.

Despite current beliefs, sugar intake is not directly associated with nonalcoholic fatty liver disease, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. Rather, high-calorie diets promote the progression of this serious form of liver disease.

Researchers conducted a double-blind study of healthy, but centrally overweight men to compare the effects of high intakes of two types of sugar, glucose and fructose, in two conditions -- weight-maintaining (moderate-calorie diet) and weight-gaining (high-calorie diet). In the weight-maintaining period, men on neither diet developed any significant changes to the liver. However, in the weight-gaining period, both diets produced equivalent features of nonalcoholic fatty liver disease, including steatosis (fatty liver) and elevated serum transaminase and triglycerides. These findings indicate that fructose and glucose have comparable effects on one's liver, and calorie intake is the factor responsible for the progression of liver disease.

"Based on the results of our study, recommending a low-fructose or low-glycemic diet to prevent nonalcoholic fatty liver disease is unjustified," said Professor Ian A. Macdonald, study author and faculty of medicine and health sciences, University of Nottingham, UK. "The best advice to give a patient is to maintain a healthy lifestyle with diet and exercise. Our study serves as a warning that even short changes in lifestyle can have profound impacts on your liver."

During the period of increased calorie intake, all study participants experienced significant increases in body weight, waist circumference and total body fat, as expected. Interestingly, satiety was unaltered in spite of weight gain during the high-calorie diet; this reinforces the notion of "hidden calories" in drinks since participants consumed a portion of their calories in liquid form.

Fructose is a simple sugar commonly found in fruits and vegetables. Glucose, also known as grape or blood sugar, is present in all major carbohydrates, such as starch and table sugar.

Nonalcoholic fatty liver disease, the most prevalent liver problem in the U.S. and most Western countries, is the buildup of extra fat in liver cells that is not caused by alcohol.


Story Source:

The above story is based on materials provided by American Gastroenterological Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Richard D. Johnston, Mary C. Stephenson, Hannah Crossland, Sally M. Cordon, Elisa Palcidi, Eleanor F. Cox, Moira A. Taylor, Guruprasad P. Aithal, Ian A. Macdonald. No Difference Between High-Fructose and High-Glucose Diets on Liver Triacylglycerol or Biochemistry in Healthy Overweight Men. Gastroenterology, 2013; 145 (5): 1016 DOI: 10.1053/j.gastro.2013.07.012

Cite This Page:

American Gastroenterological Association. "Sugar intake not directly related to liver disease." ScienceDaily. ScienceDaily, 1 November 2013. <www.sciencedaily.com/releases/2013/11/131101112406.htm>.
American Gastroenterological Association. (2013, November 1). Sugar intake not directly related to liver disease. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2013/11/131101112406.htm
American Gastroenterological Association. "Sugar intake not directly related to liver disease." ScienceDaily. www.sciencedaily.com/releases/2013/11/131101112406.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins