Featured Research

from universities, journals, and other organizations

Changing the conversation: Polymers disrupt bacterial communication

Date:
November 11, 2013
Source:
University of Nottingham
Summary:
Artificial materials based on simple synthetic polymers can disrupt the way in which bacteria communicate with each other, a new study has shown.

Artificial materials based on simple synthetic polymers can disrupt the way in which bacteria communicate with each other, a study led by scientists at The University of Nottingham has shown.

The findings, published in the journal Nature Chemistry, could further our knowledge on how better to control and exploit bacteria in the future and will have implications for work in the emerging field of synthetic biology.

Professor Cameron Alexander, in the University's School of Pharmacy, led the study. He said: "This is an exciting and unexpected finding for us and comes as a result of research which was very much curiosity driven.

"It gives us more information about how to design artificial cells and to produce materials that will interact with microorganisms and control their behaviour, with a whole host of potential applications including drug discovery and energy production."

The study, which also involved scientists from the universities of Birmingham and Newcastle, was funded by the Engineering and Physical Sciences Research Council (EPSRC), the Biotechnology and Biological Sciences Research Council (BBSRC) and The University of Nottingham.

As part of their research into the development of artificial cells and programmable bacterial coatings, the team found that polymers -- long-chain molecules -- that were able to arrange bacteria into clustered communities were, surprisingly, encouraging these bacteria to actively 'talk' to each other. This communication occurred by quorum sensing (QS), a way in which bacteria signal to each other, and coordinate response to environment. Quorum sensing also controls the way in which bacteria release certain types of molecules -- for example as a defence mechanism or as tools for infection.

This finding opens up the possibility to influence microbial behaviour by controlling their ability to form productive communities. This can be exploited to prevent the release of toxins during the spread of infection or, alternatively, the production of useful molecules which can act as drugs, food source or biofuels.

The researchers used the bioluminescent marine bacterium Vibrio harveyi, as it allows them to easily track the changes in the bacteria's behaviour by measuring the pattern and intensity of the natural light produced by the organism.

Building on some intriguing initial results, the team of pharmacists, microbiologists chemists and computer scientists were also able to produce computational models predicting and explaining the behaviour of the microbial communities, which were crucial to deduct simple design principles for the programmable interaction of bacteria and polymers.

Overall, this research offers new understanding of bacterial community behaviour and will have implications in the design of materials as antimicrobials, for bioprocessing, biocomputation and, more generally, synthetic biology.


Story Source:

The above story is based on materials provided by University of Nottingham. Note: Materials may be edited for content and length.


Journal Reference:

  1. Leong T. Lui, Xuan Xue, Cheng Sui, Alan Brown, David I. Pritchard, Nigel Halliday, Klaus Winzer, Steven M. Howdle, Francisco Fernandez-Trillo, Natalio Krasnogor, Cameron Alexander. Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes. Nature Chemistry, 2013; DOI: 10.1038/nchem.1793

Cite This Page:

University of Nottingham. "Changing the conversation: Polymers disrupt bacterial communication." ScienceDaily. ScienceDaily, 11 November 2013. <www.sciencedaily.com/releases/2013/11/131111091522.htm>.
University of Nottingham. (2013, November 11). Changing the conversation: Polymers disrupt bacterial communication. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2013/11/131111091522.htm
University of Nottingham. "Changing the conversation: Polymers disrupt bacterial communication." ScienceDaily. www.sciencedaily.com/releases/2013/11/131111091522.htm (accessed August 23, 2014).

Share This




More Plants & Animals News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Endangered Red Wolves Face Uncertain Future

Endangered Red Wolves Face Uncertain Future

AP (Aug. 22, 2014) A federal judge temporarily banned coyote hunting to save endangered red wolves, but local hunters say that the wolf preservation program does more harm than good. Meanwhile federal officials are reviewing its wolf program in North Carolina. (Aug. 22) Video provided by AP
Powered by NewsLook.com
Farm Resurgence Grows With Younger Crowd

Farm Resurgence Grows With Younger Crowd

AP (Aug. 22, 2014) New England farms are seeing a surge in younger farm hands as the 'buy local' food movement grows across the country. (Aug. 22) Video provided by AP
Powered by NewsLook.com
Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Newsy (Aug. 21, 2014) According to a new study, spiders that live in cities are bigger, fatter and multiply faster. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins