Featured Research

from universities, journals, and other organizations

Reactivation of AKT survival pathway by ERK1/2

Date:
January 7, 2014
Source:
Landes Bioscience
Summary:
In the study by Toulany et al., it was demonstrated for the first time that long term treatment with inhibitors of PI3K (as it is performed clinically) results in a reactivation of the major survival component Akt through a so far unknown regulatory loop via ERK1/2.

In a study by Toulany et al., it was demonstrated for the first time that long term treatment with inhibitors of PI3K (as it is performed clinically) results in a reactivation of the major survival component Akt through a so far unknown regulatory loop via ERK1/2.

Related Articles


This reactivation of Akt limits quite efficiently the response of the tested tumor cell lines presenting constitutively active K-Ras activity (both through K-RAS mutation or over-expression of K-RAS wildtype) to antagonistic strategies directed against PI3K. Thus, the described ERK1/2 dependency of reactivation of Akt gives new insights into the underlying mechanisms of resistance accompanying EGFR and PI3K antagonizing strategies.

Moreover and clinically perhaps even more importantly, these findings provide specific hints how the combination of MEK-ERK1/2 and PI3K inhibitors can efficiently be used to overcome therapy resistance of tumors presenting constitutively high K-Ras activity.


Story Source:

The above story is based on materials provided by Landes Bioscience. Note: Materials may be edited for content and length.


Cite This Page:

Landes Bioscience. "Reactivation of AKT survival pathway by ERK1/2." ScienceDaily. ScienceDaily, 7 January 2014. <www.sciencedaily.com/releases/2014/01/140107093325.htm>.
Landes Bioscience. (2014, January 7). Reactivation of AKT survival pathway by ERK1/2. ScienceDaily. Retrieved April 25, 2015 from www.sciencedaily.com/releases/2014/01/140107093325.htm
Landes Bioscience. "Reactivation of AKT survival pathway by ERK1/2." ScienceDaily. www.sciencedaily.com/releases/2014/01/140107093325.htm (accessed April 25, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Saturday, April 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dispute Flares Over Controversial Thai Temple Tigers

Dispute Flares Over Controversial Thai Temple Tigers

AFP (Apr. 24, 2015) Thai wildlife officials begin a headcount of nearly 150 tigers kept by monks at a temple which has become the centre of a dispute over the welfare of the animals. Video provided by AFP
Powered by NewsLook.com
College Kegger: University Gets in on Craft Brew

College Kegger: University Gets in on Craft Brew

AP (Apr. 24, 2015) Theres never been a shortage of beer on college campuses. But students at Cal Poly-Pomona are learning how to brew, serving their product to classmates, and hoping to land jobs in craft breweries when they graduate. (April 24) Video provided by AP
Powered by NewsLook.com
Cambodian Butterflies Help Villagers Make a Living

Cambodian Butterflies Help Villagers Make a Living

AFP (Apr. 24, 2015) Cambodia&apos;s Banteay Srey Butterfly Centre is the largest of its kind in Southeast Asia. As well as educating tourists about the creatures, it also offers a source of income to nearby villagers, who are paid to breed local species. Duration: 02:04 Video provided by AFP
Powered by NewsLook.com
3D Food Printing: The Meal of the Future?

3D Food Printing: The Meal of the Future?

AP (Apr. 23, 2015) Developers of 3D food printing hope the culinary technology will revolutionize the way we cook and eat. (April 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins