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Number of novel genetic defects that cause esophageal cancer discovered by scientists

Date:
March 31, 2014
Source:
National University of Singapore
Summary:
The genomic landscape of esophageal squamous carcinoma has been revealed by a team of international scientists. In this study, the researchers comprehensively investigated a large variety of genetic lesions which arose from oesophageal squamous carcinoma. The results showed enrichment of genetic abnormalities that affect several important cellular process and pathways in human cells, which promote the development of this malignancy.

Latest findings by a team of international scientists led by Singapore-based researchers reveal the genomic landscape of esophageal squamous carcinoma

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A team of scientists from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore and National University Cancer Institute Singapore (NCIS), and their collaborators from the Cedars-Sinai Medical Centre, UCLA School of Medicine, demonstrated that a number of novel genetic defects are able to induce esophageal cancer.

The research group, led by Professor H. Phillip Koeffler, Senior Principal Investigator at CSI Singapore and Deputy Director of NCIS, has conducted a successful comprehensive genomic study of esophageal squamous carcinoma, a type of very aggressive cancer prevalent in Singapore and Southeast Asia.

This novel study was first published online in the journal Nature Genetics on 30 March 2014.

In this study, the researchers comprehensively investigated a large variety of genetic lesions which arose from esophageal squamous carcinoma. The results showed enrichment of genetic abnormalities that affect several important cellular process and pathways in human cells, which promote the development of this malignancy. The scientists also uncovered a number of novel candidate genes that may make the cancer sensitive to chemotherapy. The researchers' findings provide a molecular basis for the comprehensive understanding of the pathophysiology of esophageal carcinoma as well as for developing novel therapies for this deadly disease. These groundbreaking results have immediate relevance for cancer researchers, as well as for clinical oncologists who currently do not have effective therapeutic agents to treat this type of cancer.

Dr Lin Dechen, Research Fellow at CSI Singapore and first author of the research paper, noted, "Our findings are very relevant to Singapore and the region because this disease is endemic to Southeast Asia. More importantly, many potential therapeutic drugs have surfaced from our analysis, with some of them already in use for treating other types of tumors. We are more than excited to test their efficacy in esophageal cancer."

Prof Koeffler said, "esophageal squamous cancer is one of most common causes of cancer-related death, and is particularly prevalent in Southeast Asia. We wanted to understand this major burden on the local public health system and to help find solutions. By completely investigating all human genes at the single nucleotide level, our current findings provide an enhanced road map for the study of the molecular basis underlying this somewhat neglected malignancy."

With the discovery of these previously unrecognized genetic defects, Prof Koeffler and his team will explore the detailed molecular mechanisms in the next phase of research. In addition, the scientists will evaluate whether some of these defects can be used in the clinic to cure this disease.


Story Source:

The above story is based on materials provided by National University of Singapore. Note: Materials may be edited for content and length.


Journal Reference:

  1. De-Chen Lin, Jia-Jie Hao, Yasunobu Nagata, Liang Xu, Li Shang, Xuan Meng, Yusuke Sato, Yusuke Okuno, Ana Maria Varela, Ling-Wen Ding, Manoj Garg, Li-Zhen Liu, Henry Yang, Dong Yin, Zhi-Zhou Shi, Yan-Yi Jiang, Wen-Yue Gu, Ting Gong, Yu Zhang, Xin Xu, Ori Kalid, Sharon Shacham, Seishi Ogawa, Ming-Rong Wang, H Phillip Koeffler. Genomic and molecular characterization of esophageal squamous cell carcinoma. Nature Genetics, 2014; DOI: 10.1038/ng.2935

Cite This Page:

National University of Singapore. "Number of novel genetic defects that cause esophageal cancer discovered by scientists." ScienceDaily. ScienceDaily, 31 March 2014. <www.sciencedaily.com/releases/2014/03/140331083730.htm>.
National University of Singapore. (2014, March 31). Number of novel genetic defects that cause esophageal cancer discovered by scientists. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2014/03/140331083730.htm
National University of Singapore. "Number of novel genetic defects that cause esophageal cancer discovered by scientists." ScienceDaily. www.sciencedaily.com/releases/2014/03/140331083730.htm (accessed November 22, 2014).

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