Featured Research

from universities, journals, and other organizations

Communication between nostril/skin microbiome bacteria can influence pathogen behavior

Date:
July 22, 2014
Source:
Forsyth Institute
Summary:
Scientists have made an important discovery about the molecular interactions that occur between generally benign species of Propionibacterium bacteria and the pathogenic bacterium Staphylococcus aureus, the cause of most 'staph' infections.

A team of scientists has made an important discovery about the molecular interactions that occur between generally benign species of Propionibacterium bacteria and the pathogenic bacterium Staphylococcus aureus, the cause of most "staph" infections. These bacterial species are commonly found in the human nostrils and, also, on human skin. S. aureus is a potential pathogen that inhibits the nostrils of about a quarter of all adults. It is also a common cause of skin and more invasive infections.

Related Articles


The team, led by Forsyth scientists, discovered that a small molecule secreted by skin/nostril-associated Propionibacterium species impacts the behavior of S. aureus in the lab. This research may lead to new and sustainable ways to manage the nostril-associated bacterial community to decrease infection.

S. aureus infections range in severity from mild skin infections to life threatening invasive infections. Although many people live with the bacteria in their nostrils and never get sick, having S. aureus present in the nostrils is a risk for infection. In recent years, the emergence of an antibiotic resistant form (methicillin-resistant S. aureus, or MRSA) has been a vexing problem. According to the Centers for Disease Control and Prevention, MRSA caused over 80,000 cases of invasive disease and over 10,000 annual deaths from 2005 through 2011. Community-associated or CA-MRSA imposes an annual burden of $478 million to 2.2 billion on third-party payers and $1.4-13.8 billion on society (Clinical Microbiology and Infection, June 19, 2013).

In spite of the known importance of nostril colonization as a risk for S. aureus infection, little is known about the interactions between the benign bacteria that inhabit the adult nostril and S .aureus, and what might cause this bacterium to become pathogenic. In this study, the team of researchers found that a small molecule, coproporphyrin III (CIII), excreted by Propionibacterium species found on nostril and skin surfaces causes S. aureus to aggregate and stick together, i.e., form biofilms, when grown in the laboratory. CIII induction of S. aureus aggregation is dependent on dose, the bacterium's growth phase and an acidic pH in the normal range for skin surfaces. The biofilm formation occurs in the absence of plasma proteins, which suggests that it could occur on human skin surfaces, like the lining of the nostrils.

"The emergence of antibiotic resistant S. aureus has accentuated the need to understand how the generally benign bacteria that live side-by-side with S. aureus might influence its ability to reside in the nose and on the skin where it has the opportunity to initiate infection," said Dr. Katherine Lemon, Associate Member of the Staff, Department of Microbiology at the Forsyth Institute. "This study is exciting because it is the first time that it's been demonstrated that there is a role for CIII in bacterial interspecies interactions and it shows that nostril microbiota are influenced by small-molecule-mediated interactions."


Story Source:

The above story is based on materials provided by Forsyth Institute. Note: Materials may be edited for content and length.


Cite This Page:

Forsyth Institute. "Communication between nostril/skin microbiome bacteria can influence pathogen behavior." ScienceDaily. ScienceDaily, 22 July 2014. <www.sciencedaily.com/releases/2014/07/140722130652.htm>.
Forsyth Institute. (2014, July 22). Communication between nostril/skin microbiome bacteria can influence pathogen behavior. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2014/07/140722130652.htm
Forsyth Institute. "Communication between nostril/skin microbiome bacteria can influence pathogen behavior." ScienceDaily. www.sciencedaily.com/releases/2014/07/140722130652.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Reuters - Light News Video Online (Dec. 19, 2014) Millions of monarch butterflies begin to descend onto Mexico as part of their annual migration south. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins