Featured Research

from universities, journals, and other organizations

Club cells are 'bad guys' during flu infection

Date:
August 18, 2014
Source:
The Rockefeller University Press
Summary:
A specialized subset of lung cells can shake flu infection, researchers have discovered, yet they remain stamped with an inflammatory gene signature that wreaks havoc in the lung. Seasonal flu is caused by influenza virus, which can infect a variety of cell types in the lung. Infected cells are typically destroyed by the virus itself or by immune cells that attack infected cells.

This image depicts healthy lung tissue (bottom section), damage inflicted by flu infection (middle), and reduced pathology after depletion of previously infected club cells (upper).
Credit: Emilie Clark

A specialized subset of lung cells can shake flu infection, yet they remain stamped with an inflammatory gene signature that wreaks havoc in the lung, according to a study published in The Journal of Experimental Medicine

Seasonal flu is caused by influenza virus, which can infect a variety of cell types in the lung. Infected cells are typically destroyed by the virus itself or by immune cells that attack infected cells. The resulting inflammation can linger on long after the virus has been eliminated leading to persistent symptoms and, in some cases, severe tissue damage.

Club cells are specialized cells that normally protect against inhaled microbes and pollutants. However, researchers from the Icahn School of Medicine at Mount Sinai in New York show that club cells are bad guys during flu infection. Although they are able to rid themselves of the flu virus, club cells fail to switch off expression of inflammatory genes causing prolonged pathology in the lungs even after the virus has been contained. Depletion of surviving club cells lessened destructive lung damage in flu-infected mice.

The authors confirm that human club cells show a similar inflammatory response to flu infection, so targeting club cells might be a strategy to shorten the duration of flu symptoms in humans.


Story Source:

The above story is based on materials provided by The Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nicholas S. Heaton, Ryan A. Langlois, David Sachs, Jean K. Lim, Peter Palese, and Benjamin R. Tenoever. Long-term survival of influenza virus infected club cells drives immunopathology. The Journal of Experimental Medicine, August 2014 DOI: 10.1084/jem.20140488

Cite This Page:

The Rockefeller University Press. "Club cells are 'bad guys' during flu infection." ScienceDaily. ScienceDaily, 18 August 2014. <www.sciencedaily.com/releases/2014/08/140818094642.htm>.
The Rockefeller University Press. (2014, August 18). Club cells are 'bad guys' during flu infection. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2014/08/140818094642.htm
The Rockefeller University Press. "Club cells are 'bad guys' during flu infection." ScienceDaily. www.sciencedaily.com/releases/2014/08/140818094642.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins