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Even A Little Cooling Helps After Cardiac Arrest

Date:
May 29, 2006
Source:
Elsevier Health Sciences
Summary:
As many as 400,000 people in North America suffer sudden cardiac arrest each year. Only 30 percent have their hearts restarted. Once the heart is restarted, a significant factor for subsequent death is brain injury. Cooling the patient can minimize the damage. In a paper presented at the 2006 Society for Academic Emergency Medicine Annual Meeting, May 18-21, in San Francisco, investigators from the University of Pittsburgh discussed how even slight cooling of a few degrees can help.
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As many as 400,000 people in North America suffer sudden cardiac arrest. Only 30% have their hearts restarted, and only about 6% survive to hospital discharge. Once the heart is restarted, a significant factor for subsequent death is brain injury.

In a paper presented at the 2006 Society for Academic Emergency Medicine Annual Meeting, May 18-21, in San Francisco, investigators from the University of Pittsburgh discussed the results of an animal model study to evaluate whether the simpler procedure might provide equivalent benefit.

Cooling a person by 3-4 ºC during the first day after resuscitation has been demonstrated to improve the odds of a good recovery, but few patients receive this therapy. There may be fear of complications or logistical difficulties in carrying out the therapy in most hospitals. Practically speaking, cooling a person by 2 ºC is more manageable than cooling by 4 ºC.

By using rats that had been anesthetized and subjected to cardiac arrest, the severity and duration of brain injury observed in humans was replicated. The rats were resuscitated with chest compression and epinephrine, and cranial temperatures were monitored and controlled at 37 ºC (normal), 35 ºC (2 ºC cooling) and 33 ºC (4 ºC cooling). Neurological scores were measured daily, and at the end of 14 days, their brains were examined for damage.

Rats cooled to 33 ºC did best, as measured by neurological scores, median days to return to normal, and neuron density in the hippocampus. The 35ºC group had somewhat lower results while the normal group had the worst outcomes. Overall, the benefit of cooling only 2 ºC was similar to 4 ºC cooling. These results suggest that even modest cooling of the brain might have significant benefit to humans who have been resuscitated after cardiac arrest.

The presentation is entitled "Comparison of 33ºC and 35ºC hypothermia after cardiac arrest" by Eric S Logue, Melissa R McMichael, and Clifton W Callaway MD. This paper was presented at the 2006 SAEM Annual Meeting, May 18-21, 2006, San Francisco, CA.


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Elsevier Health Sciences. "Even A Little Cooling Helps After Cardiac Arrest." ScienceDaily. ScienceDaily, 29 May 2006. <www.sciencedaily.com/releases/2006/05/060529103540.htm>.
Elsevier Health Sciences. (2006, May 29). Even A Little Cooling Helps After Cardiac Arrest. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2006/05/060529103540.htm
Elsevier Health Sciences. "Even A Little Cooling Helps After Cardiac Arrest." ScienceDaily. www.sciencedaily.com/releases/2006/05/060529103540.htm (accessed May 23, 2017).

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