In a first-of-its-kind study, scientists in Spain are reporting identification of blood proteins that seem to be involved in aspirin resistance, a condition that prevents thousands of patients from reaping aspirin's beneficial effects in protecting against heart disease and stroke.
Antonio J. Lopez-Farre and Carlos Macaya and colleagues describe what they term the first use of a powerful technology called two-dimensional electrophoresis to study changes in different proteins present in two groups of patients with coronary artery disease, the underlying cause of most heart attacks. One group of patients was aspirin-sensitive and the other had aspirin resistance.
The researchers found increased levels of three proteins involved in the binding of vitamin D in patients with aspirin resistance. They also describe additional laboratory experiments demonstrating that those proteins can inhibit aspirin's effects in preventing blood clots. "These results may aid future development of more effective therapies for aspirin-resistant patients," the study concludes.
The study "Relationship between Vitamin D Binding Protein and Aspirin Resistance in Coronary Ischemic Patients: A Proteomic Study" is scheduled for the July 6 issue of ACS's Journal of Proteome Research.
Materials provided by American Chemical Society. Note: Content may be edited for style and length.
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