Science News
from research organizations

Long-term Treatment With Proton Pump Inhibitor Can Increase Weight

October 23, 2009
World Journal of Gastroenterology
A clinical research team from Japan examined the effects of long-term proton pump inhibitor (PPI) therapy on body weight (BW) and body mass index in patients with gastroesophageal reflux disease (GERD). They concluded long-term PPI treatment was associated with BW gain in patients with GERD. Reflux patients receiving PPI should be encouraged to manage BW through lifestyle modifications.

Gastroesophageal reflux disease (GERD) is the most common esophageal disorder, and frequently encountered in the primary care setting. Accumulating evidence has confirmed the excellent efficacy and safety of proton pump inhibitor (PPI) therapy in patients with all grades of GERD, making these agents the mainstay of treatment. However, the possible impact of changes in body weight(BW) or body mass index (BMI) in reflux patients while on long-term PPI therapy has not been examined.

A clinical research team from Japan elucidatied the effect on nutritional parameters such as body weight and BMI in patients receiving long-term PPI therapy. Their study will be published on October 14, 2009 in the World Journal of Gastroenterology.

The subjects were 52 patients with GERD and 58 sex- and age-matched healthy controls. GERD patients were treated with PPI for a mean of 2.2 years (range, 0.8-5.7 years), and also advised on lifestyle modifications (e.g. selective diet, weight management). BW, BMI and other parameters were measured at baseline and end of study.

Their results showed there were no differences in BW and BMI between reflux patients and controls at baseline. Patients with GERD showed increases in BW, but no such changes were noted in the control group. Mean BW increased by 3.5 kg (6.2% of baseline) in 37 (71%) reflux patients but decreased in only 6 (12%) patients during treatment.

They concluded that reflux patients treated with a daily maintenance therapy of PPI should be strongly encouraged to manage their body weight through lifestyle modifications such as proper diet and avoidance of overeating. This measure may reduce the overall medical costs associated with obesity-related illness as well as GERD. Lifestyle modification must therefore remain the backbone of treatment for all patients with GERD, even in the PPI era.

Story Source:

Materials provided by World Journal of Gastroenterology. Note: Content may be edited for style and length.

Journal Reference:

  1. Yoshikawa I, Nagato M, Yamasaki M, Kume K, Otsuki M. Long-term treatment with proton pump inhibitor is associated with undesired weight gain. World Journal of Gastroenterology, 2009; 15 (38): 4794 DOI: 10.3748/wjg.15.4794

Cite This Page:

World Journal of Gastroenterology. "Long-term Treatment With Proton Pump Inhibitor Can Increase Weight." ScienceDaily. ScienceDaily, 23 October 2009. <>.
World Journal of Gastroenterology. (2009, October 23). Long-term Treatment With Proton Pump Inhibitor Can Increase Weight. ScienceDaily. Retrieved May 25, 2017 from
World Journal of Gastroenterology. "Long-term Treatment With Proton Pump Inhibitor Can Increase Weight." ScienceDaily. (accessed May 25, 2017).