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Body's cancer defenses hijacked to make pancreatic, lung cancers more aggressive

Date:
April 2, 2015
Source:
Cancer Research UK
Summary:
A vital self-destruct switch in cells can be hijacked, making some pancreatic and non small cell lung cancers more aggressive, according to research. Researchers found that mutations in the KRAS gene interferes with protective self-destruct switches, known as TRAIL receptors, which usually help to kill potentially cancerous cells.
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Cancer Research UK scientists have discovered that a vital self-destruct switch in cells is hijacked -- making some pancreatic and non small cell lung cancers more aggressive, according to research published in Cancer Cell.

The team, from the Cancer Research UK Centre at the UCL (University College London) Cancer Institute, found that mutations in the KRAS gene interferes with protective self-destruct switches, known as TRAIL receptors, which usually help to kill potentially cancerous cells.

The research, carried out in cancer cells and mice, shows that in cancers with faulty versions of the KRAS gene these TRAIL receptors actually help the cancer cells to grow and spread to new areas in the body.

These KRAS faults occur in 95 per cent of pancreatic cancers and 30 per cent of non small cell lung cancers.

Professor Henning Walczak, lead researcher of the study and scientific director of the Cancer Research UK-UCL Centre, said: "Our research has unveiled a new strategy used by some pancreatic and non small cell lung cancers to overcome our body's natural defences against cancer. By understanding the faults in these cancers we think we can develop more tailored treatments, which could one day provide urgently-needed options for patients with these types of pancreatic and non small cell lung cancers."

Each year in Great Britain 32,500 people are diagnosed with non small cell lung cancer and around 8,600 people are diagnosed with pancreatic cancer. Survival for these cancers has not shown much improvement for 40 years.

Nell Barrie, senior science information manager at Cancer Research UK, said: "Sadly survival from pancreatic and lung cancers remains far too low, partly because these cancers are very difficult to treat once they have spread.

"We urgently need better treatments, so it's vital to delve deeper into the molecular workings of these cancers to find ways to combat them. This research may one day help us find a way to block cancer spread, which would be a vital step to save more lives."


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Materials provided by Cancer Research UK. Note: Content may be edited for style and length.


Journal Reference:

  1. von Karstedt et al. Cancer cell-autonomous TRAIL-R signalling promotes KRAS-driven cancer progression, invasion and metastasis. Cancer Cell, April 2015 DOI: 10.1016/j.ccell.2015.02.014

Cite This Page:

Cancer Research UK. "Body's cancer defenses hijacked to make pancreatic, lung cancers more aggressive." ScienceDaily. ScienceDaily, 2 April 2015. <www.sciencedaily.com/releases/2015/04/150402132756.htm>.
Cancer Research UK. (2015, April 2). Body's cancer defenses hijacked to make pancreatic, lung cancers more aggressive. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/04/150402132756.htm
Cancer Research UK. "Body's cancer defenses hijacked to make pancreatic, lung cancers more aggressive." ScienceDaily. www.sciencedaily.com/releases/2015/04/150402132756.htm (accessed May 23, 2017).

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