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Grazoprevir/elbasvir combo shows high cure rate for patients with chronic HCV

Date:
April 24, 2015
Source:
American College of Physicians
Summary:
Once-daily oral grazoprevir/elbasvir combination therapy, taken without interferon or ribavirin for 12 weeks, demonstrated high sustained virologic response rates for treatment-naive patients with cirrhotic or non-cirrhotic chronic hepatitis C virus (HCV) genotype 1, 4, or 6. These findings suggest that once-daily oral grazoprevir/elbasvir represents a new therapeutic option for chronic HCV infection.
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Once-daily oral grazoprevir/elbasvir combination therapy, taken without interferon or ribavirin for 12 weeks, demonstrated high sustained virologic response rates for treatment-naïve patients with cirrhotic or non-cirrhotic chronic hepatitis C virus (HCV) genotype 1, 4, or 6. These findings suggest that once-daily oral grazoprevir/elbasvir represents a new therapeutic option for chronic HCV infection.

Data from the Phase 3 C-EDGE Treatment-Naïve Trial are being presented for the first time at the 50th annual congress of the European Association for the Study of the Liver in Vienna, Austria, and are published today in Annals of Internal Medicine.

In this randomized, blinded, placebo-controlled, parallel-group trial, 412 mono-infected treatment-naïve patients received either immediate or deferred therapy with grazoprevir/elbasvir. Patients in the immediate treatment group took one fixed-dose combination tablet of grazoprevir/elbasvir once daily at approximately the same time for 12 weeks.

Patients in the deferred treatment group followed the same regimen but were given matching placebo. Of the 316 patients in the immediate treatment group, 95 percent had undetectable viral load, or sustained viral response, for 12 consecutive weeks (SVR12) after treatment. SVR12 rates were 92 percent for patients with genotype 1a; 99 percent for genotype 1b; 100 percent for genotype 4; and 80 percent for genotype 6. SVR12 was achieved in 97 percent of cirrhotic patients and 94 percent of non-cirrhotic patients.


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Journal Reference:

  1. Stefan Zeuzem, Reem Ghalib, K. Rajender Reddy, Paul J. Pockros, Ziv Ben Ari, Yue Zhao, Deborah D. Brown, Shuyan Wan, Mark J. DiNubile, Bach-Yen Nguyen, Michael N. Robertson, Janice Wahl, Eliav Barr, Joan R. Butterton. Grazoprevir–Elbasvir Combination Therapy for Treatment-Naive Cirrhotic and Noncirrhotic Patients With Chronic HCV Genotype 1, 4, or 6 Infection. Annals of Internal Medicine, 2015; DOI: 10.7326/M15-0785

Cite This Page:

American College of Physicians. "Grazoprevir/elbasvir combo shows high cure rate for patients with chronic HCV." ScienceDaily. ScienceDaily, 24 April 2015. <www.sciencedaily.com/releases/2015/04/150424085634.htm>.
American College of Physicians. (2015, April 24). Grazoprevir/elbasvir combo shows high cure rate for patients with chronic HCV. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/04/150424085634.htm
American College of Physicians. "Grazoprevir/elbasvir combo shows high cure rate for patients with chronic HCV." ScienceDaily. www.sciencedaily.com/releases/2015/04/150424085634.htm (accessed May 23, 2017).

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