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Stem cell discovery paves way for targeted treatment for osteoarthritis

Date:
June 9, 2015
Source:
University of York
Summary:
Scientists have made a significant advance that could make cell-based treatments for arthritis less of a lottery. Researchers have identified individual stem cells that can regenerate tissue, cartilage and bone.
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Scientists at the University of York have made a significant advance that could make cell-based treatments for arthritis less of a lottery.

Researchers in the Departments of Biology and Physics at York, working with colleagues at the Erasmus Medical Centre in Rotterdam, have identified individual stem cells that can regenerate tissue, cartilage and bone.

The stem cells are mixed within human bone marrow stromal cells (MSCs) but are similar in appearance and previously, scientists had difficulty in distinguishing between them. The York researchers isolated individual MSCs and analysed their different properties. This allowed researchers to identify those stem cells which are capable of repairing damaged cartilage or joint tissue opening the way for improved treatment for arthritis.

The research which was funded by Arthritis Research UK is published in the latest issue of Stem Cell Reports.

The York team also isolated a rare subset of stem cells in bone marrow that while having no capability for tissue repair appeared to have a prominent role in immune function.

Dr Paul Genever, who led the research at York, said: "While stem cell therapy is an exciting new development for the treatment for osteoarthritis, up to now it has been something of a lottery because we did not know the precise properties of each of the cells.

"This project has helped us to establish which cells are good at regenerating tissue, cartilage and bone respectively. It will help in the search to develop more targeted therapies for arthritis patients."

Co-Lead author Dr James Fox said "Working with colleagues across the Arthritis Research UK Tissue Engineering Centre will help to bring our discovery closer to patient treatment."

Director of research at the charity Arthritis Research UK Dr Stephen Simpson added: "There are 8 million people in the UK living with the pain and disability caused by osteoarthritis. We are fighting to find better treatments and one day, a cure. This research is exciting and promising. Identifying specific stem cells that could help the damaged joint to repair itself, takes us a step closer to our aim of developing an injectable, safe, stem cell therapy for people with osteoarthritis."


Story Source:

Materials provided by University of York. Note: Content may be edited for style and length.


Journal Reference:

  1. Sally James, James Fox, Farinaz Afsari, Jennifer Lee, Sally Clough, Charlotte Knight, James Ashmore, Peter Ashton, Olivier Preham, Martin Hoogduijn, Raquel De Almeida Rocha Ponzoni, Y. Hancock, Mark Coles, Paul Genever. Multiparameter Analysis of Human Bone Marrow Stromal Cells Identifies Distinct Immunomodulatory and Differentiation-Competent Subtypes. Stem Cell Reports, 2015; 4 (6): 1004 DOI: 10.1016/j.stemcr.2015.05.005

Cite This Page:

University of York. "Stem cell discovery paves way for targeted treatment for osteoarthritis." ScienceDaily. ScienceDaily, 9 June 2015. <www.sciencedaily.com/releases/2015/06/150609124545.htm>.
University of York. (2015, June 9). Stem cell discovery paves way for targeted treatment for osteoarthritis. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/06/150609124545.htm
University of York. "Stem cell discovery paves way for targeted treatment for osteoarthritis." ScienceDaily. www.sciencedaily.com/releases/2015/06/150609124545.htm (accessed May 23, 2017).

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