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Extra DNA acts as a 'spare tire' for our genomes

Date:
July 6, 2015
Source:
American Chemical Society
Summary:
Carrying around a spare tire is a good thing -- you never know when you'll get a flat. Turns out we're all carrying around 'spare tires' in our genomes, too. Today researchers report that an extra set of guanines (or 'G's) in our DNA may function just like a 'spare' to help prevent many cancers from developing.
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3-D rendering of DNA structure. Various kinds of damage can happen to DNA, making it unstable, which is a hallmark of cancer.
Credit: © DigitalGenetics / Fotolia

Carrying around a spare tire is a good thing -- you never know when you'll get a flat. Turns out we're all carrying around "spare tires" in our genomes, too. Today, in ACS Central Science, researchers report that an extra set of guanines (or "G"s) in our DNA may function just like a "spare" to help prevent many cancers from developing.

Various kinds of damage can happen to DNA, making it unstable, which is a hallmark of cancer. One common way that our genetic material can be harmed is from a phenomenon called oxidative stress. When our bodies process certain chemicals or even by simply breathing, one of the products is a form of oxygen that can acutely damage DNA bases, predominantly the Gs. In order to stay cancer-free, our bodies must repair this DNA. Interestingly, where it counts -- in a regulatory DNA structure called a G-quadruplex -- the damaged G is not repaired via the typical repair mechanisms. However, people somehow do not develop cancers at the high rate that these insults occur. Cynthia Burrows, Susan Wallace and colleagues sought to unravel this conundrum.

The researchers scanned the sequences of known human oncogenes associated with cancer, and found that many contain the four G-stretches necessary for quadruplex formation and a fifth G-stretch one or more bases downstream. The team showed that these extra Gs could act like a "spare tire," getting swapped in as needed to allow damage removal by the typical repair machinery. When they exposed these quadruplex-forming sequences to oxidative stress in vitro, a series of different tests indicated that the extra Gs allowed the damages to fold out from the quadruplex structure, and become accessible to the repair enzymes. They further point out that G-quadruplexes are highly conserved in many genomes, indicating that this could be a factory-installed safety feature across many forms of life.


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Materials provided by American Chemical Society. Note: Content may be edited for style and length.


Journal Reference:

  1. Aaron M. Fleming, Jia Zhou, Susan S. Wallace, Cynthia J. Burrows. A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These “Spare Tires” Have an Evolved Function? ACS Central Science, 2015; 150706102953001 DOI: 10.1021/acscentsci.5b00202

Cite This Page:

American Chemical Society. "Extra DNA acts as a 'spare tire' for our genomes." ScienceDaily. ScienceDaily, 6 July 2015. <www.sciencedaily.com/releases/2015/07/150706114123.htm>.
American Chemical Society. (2015, July 6). Extra DNA acts as a 'spare tire' for our genomes. ScienceDaily. Retrieved May 28, 2017 from www.sciencedaily.com/releases/2015/07/150706114123.htm
American Chemical Society. "Extra DNA acts as a 'spare tire' for our genomes." ScienceDaily. www.sciencedaily.com/releases/2015/07/150706114123.htm (accessed May 28, 2017).

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