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Brain activity changes after cognitive rehabilitation, TBI study shows

Findings consistent with prior study of modified Story Memory Technique in multiple sclerosis

Date:
July 8, 2015
Source:
Kessler Foundation
Summary:
Results of a trail demonstrate for the first time significant changes in cerebral activation after memory retraining in individuals with TBI.
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Kessler Foundation researchers published results of their TBI-MEM trial, the first study to demonstrate significant changes in cerebral activation after memory retraining in individuals with traumatic brain injury (TBI). The article, "Examining the efficacy of the modified Story Memory Technique (mSMT) in persons with TBI using functional magnetic resonance imaging (fMRI): The TBI-MEM Trial" was published on July 8 by the Journal of Head Trauma Rehabilitation. The authors are Nancy Chiaravalloti, PhD, Ekaterina Dobryakova, PhD, Glenn Wylie, DPhil, and John DeLuca, PhD, of Kessler Foundation.

Eighteen participants with moderate to severe TBI were assigned to either the treatment (n=9) or placebo group (n=9). All underwent neuropsychological assessment, cognitive ability assessment and functional magnetic resonance imaging (fMRI) during a learning task before and after treatment. The treatment group was administered the modified Story Memory Technique (mSMT), a 10-session memory retraining protocol based on visualization and context; the placebo group underwent memory exercises without visualization or context training. fMRI findings showed a pattern of changes in cerebral activation in the mSMT treatment group. This is consistent with the researchers' findings in a prior study of mSMT in patients with MS, which provided the first Class I evidence for the efficacy of cognitive rehabilitation in MS.

"This is the second study we have conducted that shows significant changes in activation patterns on neuroimaging after behavioral memory intervention," said Nancy Chiaravalloti, PhD, director of Neuroscience & Neuropsychology and Traumatic Brain Injury (TBI) Research at Kessler Foundation. "These changes likely reflect increased brain efficiency and decreased task difficulty after training with mSMT. Memory deficits are a major cause of disability after TBI. Identifying effective cognitive interventions is critical to improving quality of life in this population."


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Materials provided by Kessler Foundation. Note: Content may be edited for style and length.


Journal References:

  1. Nancy D. Chiaravalloti, Ekaterina Dobryakova, Glenn R. Wylie, John DeLuca. Examining the Efficacy of the Modified Story Memory Technique (mSMT) in Persons With TBI Using Functional Magnetic Resonance Imaging (fMRI). Journal of Head Trauma Rehabilitation, 2015; 30 (4): 261 DOI: 10.1097/HTR.0000000000000164
  2. N. D. Chiaravalloti, N. B. Moore, O. M. Nikelshpur, J. DeLuca. An RCT to treat learning impairment in multiple sclerosis: The MEMREHAB trial. Neurology, 2013; 81 (24): 2066 DOI: 10.1212/01.wnl.0000437295.97946.a8

Cite This Page:

Kessler Foundation. "Brain activity changes after cognitive rehabilitation, TBI study shows: Findings consistent with prior study of modified Story Memory Technique in multiple sclerosis." ScienceDaily. ScienceDaily, 8 July 2015. <www.sciencedaily.com/releases/2015/07/150708131446.htm>.
Kessler Foundation. (2015, July 8). Brain activity changes after cognitive rehabilitation, TBI study shows: Findings consistent with prior study of modified Story Memory Technique in multiple sclerosis. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/07/150708131446.htm
Kessler Foundation. "Brain activity changes after cognitive rehabilitation, TBI study shows: Findings consistent with prior study of modified Story Memory Technique in multiple sclerosis." ScienceDaily. www.sciencedaily.com/releases/2015/07/150708131446.htm (accessed May 23, 2017).

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