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Using DNA origami to build nanodevices of the future

Date:
August 28, 2015
Source:
Institute for Integrated Cell-Material Sciences at Kyoto University
Summary:
Scientists have developed a method, using a double layer of lipids, which facilitates the assembly of DNA origami units, bringing us one-step closer to DNA nanomachines.
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Scientists have developed a method, using a double layer of lipids, which facilitates the assembly of DNA origami units, bringing us one-step closer to DNA nanomachines.
Credit: Kyoto University's Institute for Integrated Cell-Material Sciences

Scientists have developed a method, using a double layer of lipids, which facilitates the assembly of DNA origami units, bringing us one-step closer to DNA nanomachines.

Scientists have been studying ways to use synthetic DNA as a building block for smaller and faster devices. DNA has the advantage of being inherently "coded." Each DNA strand is formed of one of four "codes" that can link to only one complementary code each, thus binding two DNA strands together. Scientists are using this inherent coding to manipulate and "fold" DNA to form "origami nanostructures": extremely small two- and three-dimensional shapes that can then be used as construction material to build nanodevices such as nanomotors for use in targeted drug delivery inside the body.

Despite progress that has been made in this field, assembling DNA origami units into larger structures remains challenging.

A team of scientists at Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) has developed an approach that could bring us one step closer to the nanomachines of the future.

They used a double layer of lipids (fats) containing both a positive and a negative charge. DNA origami structures were weakly absorbed onto the lipid layer through an electrostatic interaction. The weak bond between the origami structures and the lipid layer allowed them to move more freely than in other approaches developed by scientists, facilitating their interaction with one another to assemble and form larger structures.

"We anticipate that our approach will further expand the potential applications of DNA origami structures and their assemblies in the fields of nanotechnology, biophysics and synthetic biology," says chemical biologist Professor Hiroshi Sugiyama from iCeMS.


Story Source:

Materials provided by Institute for Integrated Cell-Material Sciences at Kyoto University. Note: Content may be edited for style and length.


Journal Reference:

  1. Yuki Suzuki, Masayuki Endo, Hiroshi Sugiyama. Lipid-bilayer-assisted two-dimensional self-assembly of DNA origami nanostructures. Nature Communications, 2015; 6: 8052 DOI: 10.1038/ncomms9052

Cite This Page:

Institute for Integrated Cell-Material Sciences at Kyoto University. "Using DNA origami to build nanodevices of the future." ScienceDaily. ScienceDaily, 28 August 2015. <www.sciencedaily.com/releases/2015/08/150828121016.htm>.
Institute for Integrated Cell-Material Sciences at Kyoto University. (2015, August 28). Using DNA origami to build nanodevices of the future. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/08/150828121016.htm
Institute for Integrated Cell-Material Sciences at Kyoto University. "Using DNA origami to build nanodevices of the future." ScienceDaily. www.sciencedaily.com/releases/2015/08/150828121016.htm (accessed May 23, 2017).

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