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Revascularization before exercise program improves walking for patients with PAD

Date:
November 8, 2015
Source:
The JAMA Network Journals
Summary:
Among patients with peripheral artery disease and intermittent claudication (cramping pain in the legs due to poor circulation in the arteries, aggravated by walking), a combination therapy of endovascular revascularization (an invasive procedure to improve blood flow in an artery) followed by supervised exercise resulted in greater improvement in walking distances and health-related quality-of-life measures at one year compared with supervised exercise only, according to a new study.
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Among patients with peripheral artery disease and intermittent claudication (cramping pain in the legs due to poor circulation in the arteries, aggravated by walking), a combination therapy of endovascular revascularization (an invasive procedure to improve blood flow in an artery) followed by supervised exercise resulted in greater improvement in walking distances and health-related quality-of-life measures at one year compared with supervised exercise only, according to a study in the November 10 issue of JAMA. This issue, a cardiovascular disease theme issue, coincides with the American Heart Association's Scientific Sessions 2015.

Intermittent claudication is the classic symptomatic form of peripheral artery disease (PAD), affecting approximately 20 to 40 million people worldwide and increasing rapidly with the aging world population. Patients with claudication experience significant functional disability often resulting in a sedentary lifestyle and reduced quality of life. Supervised exercise is recommended as a first-line treatment. A combination therapy of endovascular revascularization plus supervised exercise may be beneficial, but few data comparing the two therapies are available, according to background information in the article.

M.G. Myriam Hunink, M.D., Ph.D., of the Erasmus University Medical Center, Rotterdam, the Netherlands, and colleagues randomly assigned 212 patients with PAD and intermittent claudication to endovascular revascularization plus supervised exercise (n = 106) or supervised exercise only (n = 106). The primary measured outcome for the study was the difference in maximum treadmill walking distance at 12 months between the groups.

The researchers found that endovascular revascularization plus supervised exercise (combination therapy) was associated with greater improvement in maximum walking distance compared with the supervised exercise only group, and in pain-free walking distance. Also, the combination therapy group demonstrated significantly greater improvement in health-related quality-of-life.

"The present study reopens the debate for revascularization in patients with claudication, in particular in terms of an approach using endovascular revascularization first. By improving lower extremity blood flow, early percutaneous revascularization of the target lesion gives an impulse to patient mobility and quality of life in the short-term. This, in turn, facilitates subsequent exercising and allows the patient to profit from the long-term benefits of an additional supervised exercise program," the authors write.


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Materials provided by The JAMA Network Journals. Note: Content may be edited for style and length.


Journal Reference:

  1. Farzin Fakhry, Sandra Spronk, Lijckle van der Laan, Jan J. Wever, Joep A. W. Teijink, Wolter H. Hoffmann, Taco M. Smits, Jerome P. van Brussel, Guido N. M. Stultiens, Alex Derom, P. Ted den Hoed, Gwan H. Ho, Lukas C. van Dijk, Nicole Verhofstad, Mariella Orsini, Andre van Petersen, Kristel Woltman, Ingrid Hulst, Marc R. H. M. van Sambeek, Dimitris Rizopoulos, Ellen V. Rouwet, M. G. Myriam Hunink. Endovascular Revascularization and Supervised Exercise for Peripheral Artery Disease and Intermittent Claudication. JAMA, 2015; 314 (18): 1936 DOI: 10.1001/jama.2015.14851

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The JAMA Network Journals. "Revascularization before exercise program improves walking for patients with PAD." ScienceDaily. ScienceDaily, 8 November 2015. <www.sciencedaily.com/releases/2015/11/151108125144.htm>.
The JAMA Network Journals. (2015, November 8). Revascularization before exercise program improves walking for patients with PAD. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2015/11/151108125144.htm
The JAMA Network Journals. "Revascularization before exercise program improves walking for patients with PAD." ScienceDaily. www.sciencedaily.com/releases/2015/11/151108125144.htm (accessed May 26, 2017).

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