Science News
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Environment of tumors impacts metastasis, study finds

Date:
November 16, 2015
Source:
University of Notre Dame
Summary:
The microenvironment of a tumor cell has significant impact on cancer metastasis, new research shows. This discovery has focused attention on fighting cancer in the tumor cell's microenvironment.
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If a tumor is like a seed, the soil around it plays a significant role in its growth, a new study finds.

According to the study's results, the microenvironment of a tumor cell has significant impact on cancer metastasis. This discovery by Siyuan Zhang at the University of Notre Dame and a team at the University of Texas MD Anderson Cancer Center has focused attention on fighting cancer in the tumor cell's microenvironment.

Zhang, who earned an M.D. from the Peking University Health Science Center in China and a Ph.D. from the National University of Singapore, was recruited in 2007 to the Texas team that expected to see an increase of brain metastasis when PTEN, a known tumor-inhibiting protein, was artificially deleted in a tumor cell. Results were perplexing -- sometimes there was even less metastasis in the brain -- but the group unexpectedly discovered that PTEN was reduced in tumor cells when they arrive in brain tissue. That suggested critical importance of the tissue environment, what Zhang calls the "seed and soil" model: Tumors that grow in one kind of tissue won't grow in another easily. They need to adapt to the new "soil."

"By changing the soil, we potentially can suppress metastasis," he says. "The microenvironment has tremendous impact on how the gene is expressed, what type of gene will be expressed. It's definitely not due to genetic mutation. The point of this paper is we should not overlook the huge influence of the tissue architecture, the tissue environment, the tissue composition. It's a dynamic process."

Zhang's laboratory now seeks to understand the mechanisms of the tissue-environment influence, opening the possibility that the environment could be altered in a way that fights cancer by preventing tumor cell growth. Zhang, the Nancy Dee Professor of Cancer Research, has published the breakthrough, "Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth," this month in Nature.


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Materials provided by University of Notre Dame. Note: Content may be edited for style and length.


Journal Reference:

  1. Lin Zhang, Siyuan Zhang, Jun Yao, Frank J. Lowery, Qingling Zhang, Wen-Chien Huang, Ping Li, Min Li, Xiao Wang, Chenyu Zhang, Hai Wang, Kenneth Ellis, Mujeeburahiman Cheerathodi, Joseph H. McCarty, Diane Palmieri, Jodi Saunus, Sunil Lakhani, Suyun Huang, Aysegul A. Sahin, Kenneth D. Aldape, Patricia S. Steeg, Dihua Yu. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature, 2015; 527 (7576): 100 DOI: 10.1038/nature15376

Cite This Page:

University of Notre Dame. "Environment of tumors impacts metastasis, study finds." ScienceDaily. ScienceDaily, 16 November 2015. <www.sciencedaily.com/releases/2015/11/151116152221.htm>.
University of Notre Dame. (2015, November 16). Environment of tumors impacts metastasis, study finds. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2015/11/151116152221.htm
University of Notre Dame. "Environment of tumors impacts metastasis, study finds." ScienceDaily. www.sciencedaily.com/releases/2015/11/151116152221.htm (accessed May 24, 2017).

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