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Molecule with anti-inflammatory properties in maple syrup discovered

Date:
December 22, 2015
Source:
Université Laval
Summary:
Arthritis and other inflammatory diseases could someday be treated with medication containing a molecule from maple syrup. Researchers demonstrated in a recent study that quebecol, a molecule found in maple syrup, has interesting properties for fighting the body's inflammatory response.
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Arthritis and other inflammatory diseases could someday be treated with medication containing a molecule from maple syrup. Université Laval researchers demonstrated in a recent study that quebecol, a molecule found in maple syrup, has interesting properties for fighting the body's inflammatory response.

Discovered in 2011, quebecol is the result of chemical reactions during the syrup-making process that transform the naturally occurring polyphenols in maple sap. After successfully synthesizing quebecol and its derivatives, Université Laval researchers under the supervision of Normand Voyer, a chemist with the Faculty of Science and Engineering, evaluated its anti-inflammatory properties. They called on colleague Daniel Grenier of the Faculty of Dentistry, who developed an in vitro model for determining the anti-inflammatory potential of natural molecules. "We take blood cells called macrophages and put them with bacterial toxins," explained Professor Grenier. "Macrophages usually react by triggering an inflammatory response. But if the culture medium contains an anti-inflammatory molecule, this response is blocked."

The researchers carried out tests that showed quebecol curbs the inflammatory response of macrophages, and some derivatives are even more effective than the original molecule. "The most powerful derivative has a simpler structure and is easier to synthesize than quebecol," said Normand Voyer. "This paves the way for a whole new class of anti-inflammatory agents, inspired by quebecol, that could compensate for the low efficacy of certain treatments while reducing the risk of side effects."

The study, coauthored by Sébastien Cardinal, Jabrane Azelmat, Daniel Grenier, and Normand Voyer, was published in a recent issue of the journal Bioorganic & Medicinal Chemistry Letters.


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Materials provided by Université Laval. Note: Content may be edited for style and length.


Journal Reference:

  1. Sébastien Cardinal, Jabrane Azelmat, Daniel Grenier, Normand Voyer. Anti-inflammatory properties of quebecol and its derivatives. Bioorganic & Medicinal Chemistry Letters, 2016; 26 (2): 440 DOI: 10.1016/j.bmcl.2015.11.096

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Université Laval. "Molecule with anti-inflammatory properties in maple syrup discovered." ScienceDaily. ScienceDaily, 22 December 2015. <www.sciencedaily.com/releases/2015/12/151222113148.htm>.
Université Laval. (2015, December 22). Molecule with anti-inflammatory properties in maple syrup discovered. ScienceDaily. Retrieved May 29, 2017 from www.sciencedaily.com/releases/2015/12/151222113148.htm
Université Laval. "Molecule with anti-inflammatory properties in maple syrup discovered." ScienceDaily. www.sciencedaily.com/releases/2015/12/151222113148.htm (accessed May 29, 2017).

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