Science News
from research organizations

New compounds for the treatment of infectious tropical diseases

Date:
February 10, 2016
Source:
Asociación RUVID
Summary:
Newly patented compounds show significant improvements over existing treatments, showing low toxicity and, consequently, fewer side-effects. Infectious tropical diseases mainly affect people living in developing countries. They are transmitted by the bites of insects carrying parasites that are infectious to human beings. Apart from the obvious obstacle they pose to economic and social development, these diseases are the cause of enormous human suffering and high death counts.
Share:
FULL STORY

Florenci González Adelantado.
Credit: UJI

Patented by this university, these new compounds show significant improvements over existing treatments, showing low toxicity and, consequently, fewer side-effects.

Researchers at the Universitat Jaume I (James I Univeristy, UJI) have developed new compounds for the treatment of infectious tropical diseases, such as malaria, sleeping sickness, Chagas disease and leishmaniasis. Patented by this university, these new compounds show significant improvements over existing treatments, with toxicity and, consequently, fewer side-effects.

Infectious tropical diseases mainly affect people living in developing countries. They are transmitted by the bites of insects carrying parasites that are infectious to human beings. Apart from the obvious obstacle they pose to economic and social development, these diseases are the cause of enormous human suffering and high death counts.

These new chemical compounds are UJI's response to this world health challenge. Highly selective and low-toxin, they target the disease more precisely and lead to fewer unwanted side-effects. The idea is that they be used as the basis for the development of more efficient and less toxic drugs to fight these diseases, replacing existing inefficient or more toxic alternatives.

UJI researcher Florenci González Adelantado explains how they work: "The new chemical compounds inhibit the action of the enzymes that catalyse key metabolic processes during the infection by the parasitic protozoas that cause infectious tropical diseases. Our new compounds block the natural life cycle of these enzymes, the cysteine proteases, and stop the infection from advancing, without leadig to the side-effects typical of compounds traditionally used in the treatment of these diseases."

These findings bode well for future treatment of tropical infectious diseases. They emerge from UJI's current line of reasearch into such enzyme-inhibiting structures, looking for ways to both mitigate the typical side-effects of current treatment approaches and shift even the most resistant tropical infections.


Story Source:

Materials provided by Asociación RUVID. Note: Content may be edited for style and length.


Journal Reference:

  1. Santiago Royo, Santiago Rodríguez, Tanja Schirmeister, Jochen Kesselring, Marcel Kaiser, Florenci V. González. Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action. ChemMedChem, 2015; 10 (9): 1484 DOI: 10.1002/cmdc.201500204

Cite This Page:

Asociación RUVID. "New compounds for the treatment of infectious tropical diseases." ScienceDaily. ScienceDaily, 10 February 2016. <www.sciencedaily.com/releases/2016/02/160210111729.htm>.
Asociación RUVID. (2016, February 10). New compounds for the treatment of infectious tropical diseases. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/02/160210111729.htm
Asociación RUVID. "New compounds for the treatment of infectious tropical diseases." ScienceDaily. www.sciencedaily.com/releases/2016/02/160210111729.htm (accessed May 23, 2017).

RELATED STORIES