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Proton pump inhibitors may be associated with increased risk of Dementia

Date:
February 15, 2016
Source:
The JAMA Network Journals
Summary:
The use of proton pump inhibitors, the popular medications used to treat gastroesophageal reflux and peptic ulcers, may be associated with an increased risk of dementia in a study using data from a large German health insurer.
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The use of proton pump inhibitors, the popular medications used to treat gastroesophageal reflux and peptic ulcers, may be associated with an increased risk of dementia in a study using data from a large German health insurer, according to an article published online by JAMA Neurology.

The use of proton pump inhibitors (PPIs) has increased among older patients and PPIs are among the most frequently used classes of drugs.

Britta Haenisch, Ph.D., of the German Center for Neurodegenerative Diseases, Bonn, Germany, and coauthors examined the association between the use of PPIs and the risk of dementia using data from 2004 to 2011 on inpatient and outpatient diagnoses and drug prescriptions. Regular PPI use was at least one PPI prescription in each quarter of an 18-month interval.

The study population included 218,493 individuals 75 or older before 144,814 individuals were excluded, leaving 73,679 individuals included in the final analysis. The authors identified 29,510 patients who developed dementia during the study period.

Regular users of PPIs (2,950 patients, mostly female and average age nearly 84) had a 44 percent increased risk of dementia compared with those (70,729 patients, mostly female and average age 83) not receiving PPI medication, according to the results.

Limitations to the study include the authors only being able to integrate some other risk factors for dementia into the analysis from the data.

"The present study can only provide a statistical association between PPI use and risk of dementia. The possible underlying causal biological mechanism has to be explored in future studies. To evaluate and establish direct cause and effect relationships between PPI use and incident dementia in the elderly, randomized, prospective clinical trials are needed," the study concludes.


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Materials provided by The JAMA Network Journals. Note: Content may be edited for style and length.


Journal References:

  1. Willy Gomm, Klaus von Holt, Friederike Thomé, Karl Broich, Wolfgang Maier, Anne Fink, Gabriele Doblhammer, Britta Haenisch. Association of Proton Pump Inhibitors With Risk of Dementia. JAMA Neurology, 2016; DOI: 10.1001/jamaneurol.2015.4791
  2. Lewis H. Kuller. Do Proton Pump Inhibitors Increase the Risk of Dementia? JAMA Neurology, 2016; DOI: 10.1001/jamaneurol.2015.4931

Cite This Page:

The JAMA Network Journals. "Proton pump inhibitors may be associated with increased risk of Dementia." ScienceDaily. ScienceDaily, 15 February 2016. <www.sciencedaily.com/releases/2016/02/160215113911.htm>.
The JAMA Network Journals. (2016, February 15). Proton pump inhibitors may be associated with increased risk of Dementia. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/02/160215113911.htm
The JAMA Network Journals. "Proton pump inhibitors may be associated with increased risk of Dementia." ScienceDaily. www.sciencedaily.com/releases/2016/02/160215113911.htm (accessed May 23, 2017).

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