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Vision restored in rabbits following stem cell transplantation

Date:
March 9, 2016
Source:
Cardiff University
Summary:
Scientists have demonstrated a method for generating several key types of eye tissue from human stem cells in a way that mirrors whole eye development.
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Rabbit eye. (stock image)
Credit: © Nneirda / Fotolia

Scientists have demonstrated a method for generating several key types of eye tissue from human stem cells in a way that mirrors whole eye development.

When transplanted to an animal model of corneal blindness, these tissues are shown to repair the front of the eye and restore vision, which scientists say could pave the way for human clinical trials of anterior eye transplantation to restore lost or damaged vision.

A collaborative team comprising researchers from Cardiff University and Osaka University in Japan describe their findings today in Nature.

The eye is composed of highly specialized tissues that are derived from a variety of cell lineages during development.

Previous studies have demonstrated that particular cell types, such as those that constitute the retina or cornea, can be created in the laboratory from pluripotent stem cells. However, these studies do not represent the complexity of whole eye development.

This latest study reports the generation of multiple cell lineages of the eye, including the lens, cornea, and conjunctiva, using human induced pluripotent stem cells.

The scientists have been able to show that the corneal epithelial cells can be cultivated and transplanted onto the eyes of rabbits with experimentally induced blindness to surgically repair the front of the eye.

Study co-author Professor Andrew Quantock, from Cardiff University's School of Optometry and Vision Sciences, said: "This research shows that various types of human stem cells are able to take on the characteristics of the cornea, lens and retina.

"Importantly, it demonstrates that one cell type -- the corneal epithelium -- could be further grown in the lab and then transplanted on to a rabbit's eye where it was functional, achieving recovered vision.

"Our work not only holds potential for developing cells for treatment of other areas of the eye, but could set the stage for future human clinical trials of anterior eye transplantation to restore visual function."

Around 4000 corneal grafts are performed by the NHS annually, which rely on human organ donation.

The research was funded by the Japanese government's Agency for Medical Research and Development.


Story Source:

Materials provided by Cardiff University. Note: Content may be edited for style and length.


Journal Reference:

  1. Haotian Lin, Hong Ouyang, Jie Zhu, Shan Huang, Zhenzhen Liu, Shuyi Chen, Guiqun Cao, Gen Li, Robert A. J. Signer, Yanxin Xu, Christopher Chung, Ying Zhang, Danni Lin, Sherrina Patel, Frances Wu, Huimin Cai, Jiayi Hou, Cindy Wen, Maryam Jafari, Xialin Liu, Lixia Luo, Jin Zhu, Austin Qiu, Rui Hou, Baoxin Chen, Jiangna Chen, David Granet, Christopher Heichel, Fu Shang, Xuri Li, Michal Krawczyk, Dorota Skowronska-Krawczyk, Yujuan Wang, William Shi, Daniel Chen, Zheng Zhong, Sheng Zhong, Liangfang Zhang, Shaochen Chen, Sean J. Morrison, Richard L. Maas, Kang Zhang, Yizhi Liu. Lens regeneration using endogenous stem cells with gain of visual function. Nature, 2016; DOI: 10.1038/nature17181

Cite This Page:

Cardiff University. "Vision restored in rabbits following stem cell transplantation." ScienceDaily. ScienceDaily, 9 March 2016. <www.sciencedaily.com/releases/2016/03/160309135708.htm>.
Cardiff University. (2016, March 9). Vision restored in rabbits following stem cell transplantation. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2016/03/160309135708.htm
Cardiff University. "Vision restored in rabbits following stem cell transplantation." ScienceDaily. www.sciencedaily.com/releases/2016/03/160309135708.htm (accessed May 26, 2017).

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