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How skeletal stem cells form the blueprint of the face

Date:
April 22, 2016
Source:
University of Southern California - Health Sciences
Summary:
Timing is everything when it comes to the development of the vertebrate face. In a new study, researchers have identified the roles of key molecular signals that control this critical timing.
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A three-day-old zebrafish head skeleton with newly differentiated cartilage cells (magenta) emerges from a pool of skeletal progenitor cells (green).
Credit: Lindsey Barske/Crump Lab

Timing is everything when it comes to the development of the vertebrate face. In a new study published in PLoS Genetics, USC Stem Cell researcher Lindsey Barske from the laboratory of Gage Crump and her colleagues identify the roles of key molecular signals that control this critical timing.

Previous work from the Crump and other labs demonstrated that two types of molecular signals, called Jagged-Notch and Endothelin1 (Edn1), are critical for shaping the face. Loss of these signals results in facial deformities in both zebrafish and humans, revealing these as essential for patterning the faces of all vertebrates.

Using sophisticated genetic, genomic and imaging tools to study zebrafish, the researchers discovered that Jagged-Notch and Edn1 work in tandem to control where and when stem cells turn into facial cartilage. In the lower face, Edn1 signals accelerate cartilage formation early in development. In the upper face, Jagged-Notch signals prevent stem cells from making cartilage until later in development. The authors found that these differences in the timing of stem cells turning into cartilage play a major role in making the upper and lower regions of the face distinct from one another.

"We've shown that the earliest blueprint of the facial skeleton is set up by spatially intersecting signals that control when stem cells turn into cartilage or bone. Logically, therefore, small shifts in the levels of these signals throughout evolution could account for much of the diversity of shapes we see within the skulls of different animals, as well as the wonderful array of facial shapes seen in humans," said Barske, lead author and A.P. Giannini postdoctoral research fellow.


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Materials provided by University of Southern California - Health Sciences. Original written by Cristy Lytal. Note: Content may be edited for style and length.


Journal Reference:

  1. Lindsey Barske, Amjad Askary, Elizabeth Zuniga, Bartosz Balczerski, Paul Bump, James T. Nichols, J. Gage Crump. Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face. PLOS Genetics, 2016; 12 (4): e1005967 DOI: 10.1371/journal.pgen.1005967

Cite This Page:

University of Southern California - Health Sciences. "How skeletal stem cells form the blueprint of the face." ScienceDaily. ScienceDaily, 22 April 2016. <www.sciencedaily.com/releases/2016/04/160422115617.htm>.
University of Southern California - Health Sciences. (2016, April 22). How skeletal stem cells form the blueprint of the face. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2016/04/160422115617.htm
University of Southern California - Health Sciences. "How skeletal stem cells form the blueprint of the face." ScienceDaily. www.sciencedaily.com/releases/2016/04/160422115617.htm (accessed May 26, 2017).

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