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Revealed: New insights on causes of sudden cardiac death in the young

Date:
June 22, 2016
Source:
University of Sydney
Summary:
Genetic testing has shed new light on the deaths of nearly 500 young Australians and New Zealanders who died from sudden cardiac death in a three-year period, suggests a new report.
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Genetic testing has shed new light on the deaths of nearly 500 young Australians and New Zealanders who died from sudden cardiac death in a 3-year period, the New England Journal of Medicine reports today.

"Sudden cardiac death in children and young adults has a devastating impact on families, care providers and the community," says the University of Sydney's Professor Chris Semsarian, who led the multinational study.

"It's a tragedy that claims the lives of two to three young Australians each week.

"Sudden cardiac death is a sudden, unexpected death in an otherwise healthy person occurring within an hour of symptom onset, or when unwitnessed, within 24 hours of the person last being seen in good health," says Professor Semsarian who is also Head of the Molecular Cardiology Program at The Centenary Institute, and cardiologist at Royal Prince Alfred Hospital in Sydney, Australia.

To source the cause of these deaths, researchers prospectively investigated all 490 cases of sudden cardiac death (SCD) occurring among people aged one to 35 years from 2010 to 2012.

Key results

They found a cause of death in 60 per cent of cases (292) by reviewing information from autopsies, coronial and police reports. Most of these deaths were explained by coronary artery disease (24 per cent), inherited cardiomyopathies (16 per cent), myocarditis (7 per cent) and aortic dissection (4 per cent).

However, the remaining 40 per cent (198) of cases were initially unexplained at autopsy.

To shed light on these, researchers obtained permission to analyse blood from many of these cases and do clinical screening among family members.

Testing found that one in four (27 per cent) unexplained sudden cardiac deaths had a clinically relevant genetic mutation, despite these people having structurally normal hearts.

Age level analysis revealed that 31 to 35 year-olds had the highest incidence of SCD while 16-20 year-olds had the highest incidence of unexplained SCD deaths.

Also, most SCD cases occurred during sleep (38 per cent) or rest (27 per cent), questioning the efficacy of limiting strenuous physical activity as a way to reduce SCD among children and young adults.

"Making a clear genetic diagnosis in cases of unexplained sudden cardiac death in a young person has implications for surviving relatives," says Professor Semsarian.

"Pinpointing the underlying cause can save the lives of others and bring some comfort to devastated families, especially when many of these deaths go unexplained."

The study's first author, Dr Richard Bagnall, a genetic researcher at the Centenary Institute said: "Identifying the hidden genetic causes of sudden cardiac deaths has important benefits. For example, genetic testing of surviving family members provides information that can inform prevention and reproductive options."

Beyond preventive advice and clinical care for at-risk family members, Semsarian says there are three ways to reduce sudden cardiac deaths in the broader community:

  • Raise awareness -- anyone who has had blackouts during exercise or a family history of genetic heart disorder may be at high-risk of sudden cardiac death. These people should see their GP to discuss a screening test.
  • Teach CPR in schools, sports clubs, workplaces and community settings.
  • Increase the availability of defibrillators and people trained to use them in schools, sports clubs and community venues.

In December 2015, the NSW Government supported Professor Semsarian's long campaign to end red tape that was preventing the presence of defibrillators in New South Wales government schools. Following this, NSW overturned the NSW Department of Education's policy and permitted the installation of defibrillators and supported comprehensive CPR training in all schools in NSW.


Story Source:

Materials provided by University of Sydney. Note: Content may be edited for style and length.


Journal Reference:

  1. Richard D. Bagnall, Ph.D. et al. A Prospective Study of Sudden Cardiac Death among Children and Young Adults. NEJM, June 2016 DOI: 10.1056/NEJMoa1510687

Cite This Page:

University of Sydney. "Revealed: New insights on causes of sudden cardiac death in the young." ScienceDaily. ScienceDaily, 22 June 2016. <www.sciencedaily.com/releases/2016/06/160622192414.htm>.
University of Sydney. (2016, June 22). Revealed: New insights on causes of sudden cardiac death in the young. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2016/06/160622192414.htm
University of Sydney. "Revealed: New insights on causes of sudden cardiac death in the young." ScienceDaily. www.sciencedaily.com/releases/2016/06/160622192414.htm (accessed May 24, 2017).

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