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Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells

Date:
August 23, 2016
Source:
Aalto University
Summary:
A discovery in the field of biomaterials may open new frontiers in stem and cancer cell manipulation and associated advanced therapy development. Novel scaffolds are shown enabling cells to behave in a different but controlled way in vitro due to the presence of aligned, self-assembled ceramic nanofibers of an ultra-high anisotropy ratio augmented into graphene shells.
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A discovery in the field of biomaterials may open new frontiers in stem and cancer cell manipulation and associated advanced therapy development. Novel scaffolds are shown enabling cells to behave in a different but controlled way in vitro due to the presence of aligned, self-assembled ceramic nanofibers of an ultra-high anisotropy ratio augmented into graphene shells.

"This unique hybrid nano-network allows for an exceptional combination of selective guidance stimuli for stem cell development, variations in immune reactions, and behavior of cancer cells," says Professor Michael Gasik from Aalto University.

These scaffolds, for example, were shown to be able to direct the preferential orientation of human mesenchymal stem cells, similarly to neurogenic lineage, to suppress of major inflammatory factors expression and to immobilize cancer cells.

The selective downregulation of specific inflammatory cytokines may be anticipated as a new tool for understanding the human immune system and ways of treating associated diseases. The effects observed are self-regulated by cells only, without the side effects usually arising from the use of external factors.

New scaffolds may help to control the fate of stem cells, such as development towards axons and neurites formation. This is important, for instance, in the development of Alzheimer's disease therapy. The discovery may also be very useful in developing new cancer tumour models, understanding how cancer develops, and developing new cancer therapies.


Story Source:

Materials provided by Aalto University. Note: Content may be edited for style and length.


Journal Reference:

  1. Jekaterina Kazantseva, Roman Ivanov, Michael Gasik, Toomas Neuman, Irina Hussainova. Graphene-augmented nanofiber scaffolds demonstrate new features in cells behaviour. Scientific Reports, 2016; 6: 30150 DOI: 10.1038/srep30150

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Aalto University. "Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells." ScienceDaily. ScienceDaily, 23 August 2016. <www.sciencedaily.com/releases/2016/08/160823111957.htm>.
Aalto University. (2016, August 23). Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2016/08/160823111957.htm
Aalto University. "Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells." ScienceDaily. www.sciencedaily.com/releases/2016/08/160823111957.htm (accessed May 26, 2017).

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