New! Sign up for our free email newsletter.
Science News
from research organizations

Research into fly development provides insights into blood vessel formation

Date:
September 29, 2016
Source:
Institute for Research in Biomedicine-IRB
Summary:
Researchers working with flies describe that the concentration of some small intracellular organelles determines the branching capacity of tracheal cells. Tracheal cells are analogous to the cells that form blood vessels in the human body. The inhibition or stimulation of new blood vessels has implications in cancer and in tissue regeneration.
Share:
FULL STORY

Researchers working with flies at IRB Barcelona describe that the concentration of some small intracellular organelles determines the branching capacity of tracheal cells.

Tracheal cells are analogous to the cells that form blood vessels in the human body. The inhibition or stimulation of new blood vessels has implications in cancer and in tissue regeneration.

Published in Current Biology, a study by Sofia J. Araújo, associate researcher at the Institute for Research in Biomedicine (IRB Barcelona), reveals that the number of centrosomes -- small intracellular structures -- in cells determines the final shape that cells adopt and their function.

The effects of variations in the number of centrosomes are studied mainly in dividing cells because of the key function of centrosomes in this process and their correlation with cancer when defects are present. Araújo's team, which works in Jordi Casanova's Development and Morphogenesis in Drosophila Lab, has now addressed the influence of variations in centrosome number on cells that have already divided and differentiated. They demonstrate that centrosomes are also determinant organelles in cells that have already left the cell-division cycle.

The greater the number of centrosomes, the greater the branching in the trachea

The scientists have studied centrosomes in the tracheal cells of the fly Drosophila melanogaster. In the article, they demonstrate that cells that hold more than two centrosomes form more branches (a single cell is like a small tree with many branches). In contrast, those that have two (the usual number) form standard branches, while those that have none show practically no branching.

This finding indicates variations in the number of centrosomes affect the morphology of tracheal cells. In addition, the study describes that the number of centrosomes is related to the first developmental stages of these structures in the fly respiratory system. "Through our work, we have been able to modify the capacity of these cells to branch in function of the number of centrosomes that we introduce. This finding may have biomedical implications," says Araújo.

Of biomedical interest

Tracheal cells are homologous structures to the cells that form the delicate blood vessels of the human body. The formation of new vessels (from those already existing (angiogenesis) or new ones (neovascularisation) has two implications in human health. On the one hand, medical practice seeks how to inhibit pathological angiogenesis, for example in cancer, when tumour cells generate more blood vessels to facilitate access to more oxygen and nutrients, thus ensuring their growth. On the other hand, and in contrast, it may be of interest to stimulate the formation of new vessels, for example for wound healing or in regenerative processes.

Beyond the widely studied effects of centrosomes on cell division, the work by Araújo provides new information on the function of these organelles and their possible contribution to disease in differentiated cells.


Story Source:

Materials provided by Institute for Research in Biomedicine-IRB. Note: Content may be edited for style and length.


Journal Reference:

  1. Delia Ricolo, Myrto Deligiannaki, Jordi Casanova and Sofia J. Araújo. Centrosome amplification increases single-cell branching in post-mitotic cells. Current Biology, September 2016 DOI: 10.1016/j.cub.2016.08.020

Cite This Page:

Institute for Research in Biomedicine-IRB. "Research into fly development provides insights into blood vessel formation." ScienceDaily. ScienceDaily, 29 September 2016. <www.sciencedaily.com/releases/2016/09/160929132504.htm>.
Institute for Research in Biomedicine-IRB. (2016, September 29). Research into fly development provides insights into blood vessel formation. ScienceDaily. Retrieved March 28, 2024 from www.sciencedaily.com/releases/2016/09/160929132504.htm
Institute for Research in Biomedicine-IRB. "Research into fly development provides insights into blood vessel formation." ScienceDaily. www.sciencedaily.com/releases/2016/09/160929132504.htm (accessed March 28, 2024).

Explore More

from ScienceDaily

RELATED STORIES