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BMI genotype and breast cancer risk

Date:
October 3, 2016
Source:
Vanderbilt University Medical Center
Summary:
Being overweight is associated with decreased risk of breast cancer before menopause and increased risk after menopause, report scientists.
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Being overweight is associated with decreased risk of breast cancer before menopause and increased risk after menopause.

In a study published recently in PLOS Medicine, Wei Zheng, Ph.D., M.D., and colleagues investigate these contrasting associations.

They use data from 145,056 women, and a list of genetic variants found in genomic studies to be associated with BMI. Estimating each woman's BMI based strictly on genotype, the team found that genetically predicted high BMI was associated with a reduced risk of breast cancer in both premenopausal and postmenopausal women.

"It is likely that genetically predicted BMI may be more closely related to body weight in early life, which is negatively associated with breast cancer risk. Measured high BMI later in life may be influenced primarily by environmental factors that are associated with increased risk of breast cancer. For breast cancer prevention, the study provides evidence for lifestyle modification to reduce weight gain in adults," Zheng said.


Story Source:

Materials provided by Vanderbilt University Medical Center. Original written by Paul Govern. Note: Content may be edited for style and length.


Journal Reference:

  1. Yan Guo, Shaneda Warren Andersen, Xiao-Ou Shu, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Montserrat Garcia-Closas, Roger L. Milne, Marjanka K. Schmidt, Jenny Chang-Claude, Allison Dunning, Stig E. Bojesen, Habibul Ahsan, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Matthias W. Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, Natalia V. Bogdanova, Bernardo Bonanni, Anne-Lise Børresen-Dale, Judith Brand, Hiltrud Brauch, Hermann Brenner, Thomas Brüning, Barbara Burwinkel, Graham Casey, Georgia Chenevix-Trench, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Peter Devilee, Thilo Dörk, Martine Dumont, Peter A. Fasching, Jonine Figueroa, Dieter Flesch-Janys, Olivia Fletcher, Henrik Flyger, Florentia Fostira, Marilie Gammon, Graham G. Giles, Pascal Guénel, Christopher A. Haiman, Ute Hamann, Maartje J. Hooning, John L. Hopper, Anna Jakubowska, Farzana Jasmine, Mark Jenkins, Esther M. John, Nichola Johnson, Michael E. Jones, Maria Kabisch, Muhammad Kibriya, Julia A. Knight, Linetta B. Koppert, Veli-Matti Kosma, Vessela Kristensen, Loic Le Marchand, Eunjung Lee, Jingmei Li, Annika Lindblom, Robert Luben, Jan Lubinski, Kathi E. Malone, Arto Mannermaa, Sara Margolin, Frederik Marme, Catriona McLean, Hanne Meijers-Heijboer, Alfons Meindl, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, Janet E. Olson, Jose I. A. Perez, Barbara Perkins, Paolo Peterlongo, Kelly-Anne Phillips, Katri Pylkäs, Anja Rudolph, Regina Santella, Elinor J. Sawyer, Rita K. Schmutzler, Caroline Seynaeve, Mitul Shah, Martha J. Shrubsole, Melissa C. Southey, Anthony J. Swerdlow, Amanda E. Toland, Ian Tomlinson, Diana Torres, Thérèse Truong, Giske Ursin, Rob B. Van Der Luijt, Senno Verhoef, Alice S. Whittemore, Robert Winqvist, Hui Zhao, Shilin Zhao, Per Hall, Jacques Simard, Peter Kraft, Paul Pharoah, David Hunter, Douglas F. Easton, Wei Zheng. Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent. PLOS Medicine, 2016; 13 (8): e1002105 DOI: 10.1371/journal.pmed.1002105

Cite This Page:

Vanderbilt University Medical Center. "BMI genotype and breast cancer risk." ScienceDaily. ScienceDaily, 3 October 2016. <www.sciencedaily.com/releases/2016/10/161003131123.htm>.
Vanderbilt University Medical Center. (2016, October 3). BMI genotype and breast cancer risk. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2016/10/161003131123.htm
Vanderbilt University Medical Center. "BMI genotype and breast cancer risk." ScienceDaily. www.sciencedaily.com/releases/2016/10/161003131123.htm (accessed May 26, 2017).

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