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Gene deletion points way to flu treatment

Date:
October 19, 2016
Source:
Houston Methodist
Summary:
Researchers kept mice from getting the flu by removing a gene that regulates their immune system. According to the study, mice missing the gene Trim29 eliminated human influenza virus within 48 hours, protecting them from infection.
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Researchers at Houston Methodist kept mice from getting the flu by removing a gene that regulates their immune system. According to a study recently published in Nature Immunology, mice missing the gene Trim29 eliminated human influenza virus within 48 hours, protecting them from infection.

"Influenza is the leading cause of death from infections worldwide. An effective treatment is vital, especially for children, the elderly and patients with compromised immune systems," said Zhiqiang Zhang, Ph.D., the paper's lead author and assistant member of transplant immunology at Houston Methodist Research Institute. "Mice lacking Trim29 kept them from a full blown infection and completely cleared them of the virus. This finding points the way to a potential flu treatment."

Immune cells around the lungs are the first line of defense against infections. The gene Trim29, or Tripartite Interaction Motif 29, controls activation of lung immune cells after viral infections. Zhang's team infected mice without the gene with the H1N1 flu virus and compared their survival and amount of virus to normal mice. Mice lacking Trim29 survived with no detectable infection or virus.


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Materials provided by Houston Methodist. Note: Content may be edited for style and length.


Journal Reference:

  1. Junji Xing, Leiyun Weng, Bin Yuan, Zhuo Wang, Li Jia, Rui Jin, Hongbo Lu, Xian Chang Li, Yong-Jun Liu, Zhiqiang Zhang. Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract. Nature Immunology, 2016; DOI: 10.1038/ni.3580

Cite This Page:

Houston Methodist. "Gene deletion points way to flu treatment." ScienceDaily. ScienceDaily, 19 October 2016. <www.sciencedaily.com/releases/2016/10/161019122558.htm>.
Houston Methodist. (2016, October 19). Gene deletion points way to flu treatment. ScienceDaily. Retrieved May 25, 2017 from www.sciencedaily.com/releases/2016/10/161019122558.htm
Houston Methodist. "Gene deletion points way to flu treatment." ScienceDaily. www.sciencedaily.com/releases/2016/10/161019122558.htm (accessed May 25, 2017).

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