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Acid suppression medications linked to serious gastrointestinal infections

Date:
January 5, 2017
Source:
Wiley
Summary:
In a population-based study from Scotland, use of commonly-prescribed acid suppression medications such as proton pump inhibitors (PPIs) was linked with an increased risk of intestinal infections with C. difficile and Campylobacter bacteria, which can cause considerable illness.
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In a population-based study from Scotland, use of commonly-prescribed acid suppression medications such as proton pump inhibitors (PPIs) was linked with an increased risk of intestinal infections with C. difficile and Campylobacter bacteria, which can cause considerable illness.

Compared with individuals in the community who did not take acid suppression medications, those who did had 1.7-times and 3.7-times increased risks of C. difficile and Campylobacter, respectively. Among hospitalized patients, those using the medications had 1.4-times and 4.5-times increased risks, respectively.

Although acid suppression therapy is often considered relatively free from side effects, the findings suggest that there are significant adverse gastrointestinal consequences of their use. "Users of these medications should be particularly vigilant about food hygiene as the removal of stomach acid makes them more easily infected with agents such as Campylobacter, which is commonly found on poultry," said Prof. Thomas MacDonald, senior author of the British Journal of Clinical Pharmacology study.


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Journal Reference:

  1. Li Wei, Lasantha Ratnayake, Gabby Phillips, Chris C. McGuigan, Steve V. Morant, Robert W. Flynn, Isla S. Mackenzie, Thomas M. MacDonald. Acid suppression medications and bacterial gastroenteritis: a population-based cohort study. British Journal of Clinical Pharmacology, 2016; DOI: 10.1111/bcp.13205

Cite This Page:

Wiley. "Acid suppression medications linked to serious gastrointestinal infections." ScienceDaily. ScienceDaily, 5 January 2017. <www.sciencedaily.com/releases/2017/01/170105082813.htm>.
Wiley. (2017, January 5). Acid suppression medications linked to serious gastrointestinal infections. ScienceDaily. Retrieved May 29, 2017 from www.sciencedaily.com/releases/2017/01/170105082813.htm
Wiley. "Acid suppression medications linked to serious gastrointestinal infections." ScienceDaily. www.sciencedaily.com/releases/2017/01/170105082813.htm (accessed May 29, 2017).

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