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Evolutionary advantage of the common periwinkle

Adding one heavy-metal-binding domain in a cysteine-rich protein may be one of the sea snail's adaptations to metal stress

Date:
March 24, 2017
Source:
Wiley
Summary:
A special kind of small sulfur-rich proteins, the metallothioneins, have an extraordinarily large capability for binding heavy metals. An international team of scientists has now discovered that the marine common periwinkle, which is widely considered a delicacy, contains the largest version of the protein found yet, with one additional cadmium-binding domain and a one-third higher detoxification capacity. This feature may help the snail survive in heavy-metal-polluted environments.
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A special kind of small sulfur-rich proteins, the metallothioneins, have an extraordinarily large capability for binding heavy metals. An international team of scientists has now discovered that the marine common periwinkle, which is widely considered a delicacy, contains the largest version of the protein found yet, with one additional cadmium-binding domain and a one-third higher detoxification capacity. As they report in the journal Angewandte Chemie, this feature may help the snail survive in heavy-metal-polluted environments.

Snails and slugs are known for their intriguing ability to accumulate and detoxify heavy metals. They are even capable of discriminating between cadmium and copper, as the latter element is an indispensable element in their metabolism, while cadmium is toxic. They detoxify cadmium by binding it to metallothioneins, a class of small proteins rich in the sulfur-containing cysteine amino acid. Oliver Zerbe at the University of Zurich, Switzerland, and Reinhard Dallinger at the University of Innsbruck, Austria, and their colleagues in Barcelona, Spain, investigate the evolution of these proteins as a strategy to adapt the gastropodes to their new habitats -- land snails have developed from marine species, and had to find novel strategies to cope with the higher loadings of heavy metals in the soil. Still harsher environments are found at the sea shores with their fluctuating water supply. As the scientists discovered, the marine gastropod Littorina littorea (common periwinkle), which has very successfully colonized the Northern Atlantic shores, has found a peculiarstrategy for even more efficient detoxification.

Studying the molecular differences between the proteins among various species, the scientists solved the solution structure of the periwinkle metallothionein by using nuclear magnetic resonance techniques and compared it with other known structures and sequences. Surprisingly, the periwinkle's protein comprises three independent domains, while other known metallothioneins have only one or two. Each of the three domains contains nine cystein residues binding a cluster of three cadmium ions, thus the total 27 cystein residues can incorporate nine cadmium ions. This sheds light on the adaptation strategy: "Increasing the number of domains simply increases the metal-binding capacity of the protein and thereby potentiates its metal-detoxification capacity," the authors wrote.

Regarding the structural features, the complex formed with cadmium is very similar to that of the Roman snail form, which can efficiently discriminate between the copper ions vital to snails and toxic cadmium. And apart from simply coping with cadmium-rich environments and selecting copper from other heavy metals, the cysteine-rich metallothioneins are considered as important oxidative-stress-response proteins. Stress is one of the major encounters of the common periwinkle, which can survive rough seas and drought at the same time.


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Journal Reference:

  1. Christian Baumann, Andrea Beil, Simon Jurt, Michael Niederwanger, Oscar Palacios, Mercè Capdevila, Sílvia Atrian, Reinhard Dallinger, Oliver Zerbe. Structural Adaptation of a Protein to Increased Metal Stress: NMR Structure of a Marine Snail Metallothionein with an Additional Domain. Angewandte Chemie International Edition, 2017; DOI: 10.1002/anie.201611873

Cite This Page:

Wiley. "Evolutionary advantage of the common periwinkle: Adding one heavy-metal-binding domain in a cysteine-rich protein may be one of the sea snail's adaptations to metal stress." ScienceDaily. ScienceDaily, 24 March 2017. <www.sciencedaily.com/releases/2017/03/170324104845.htm>.
Wiley. (2017, March 24). Evolutionary advantage of the common periwinkle: Adding one heavy-metal-binding domain in a cysteine-rich protein may be one of the sea snail's adaptations to metal stress. ScienceDaily. Retrieved April 29, 2017 from www.sciencedaily.com/releases/2017/03/170324104845.htm
Wiley. "Evolutionary advantage of the common periwinkle: Adding one heavy-metal-binding domain in a cysteine-rich protein may be one of the sea snail's adaptations to metal stress." ScienceDaily. www.sciencedaily.com/releases/2017/03/170324104845.htm (accessed April 29, 2017).