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How to measure potentially damaging free radicals in cigarette smoke

Date:
March 29, 2017
Source:
American Chemical Society
Summary:
Smoking cigarettes can lead to illness and death. Free radicals, which are atoms or groups of atoms with unpaired electrons, in inhaled smoke are thought to be partly responsible for making smokers sick. Now researchers report a method for measuring free radicals in cigarette smoke that could help improve our understanding of the relationship between these substances and health.
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Smoking cigarettes can lead to illness and death. Free radicals, which are atoms or groups of atoms with unpaired electrons, in inhaled smoke are thought to be partly responsible for making smokers sick. Now researchers report in ACS' journal Chemical Research in Toxicology a method for measuring free radicals in cigarette smoke that could help improve our understanding of the relationship between these substances and health.

Cigarette smoking is the leading preventable cause of death in the U.S., according to the Centers for Disease Control and Prevention. Understanding why is a challenge, given that cigarette smoke is a complex mixture of more than 7,000 compounds. Much of the blame has been placed on the 93 cigarette-related carcinogens and toxins on the U.S. Food and Drug Administration's list of hazardous and potentially hazardous chemicals. But previous studies have reported that risk assessments based on these compounds underestimate the actual number of illnesses caused by smoking. Accounting for free radicals, which are known to cause oxidative damage in the body, could help fill that gap. But they are not listed on the FDA's list and are difficult to study because they don't stick around for long. So John P. Richie Jr. and colleagues wanted to find a reliable way to measure free radicals in cigarette smoke.

The researchers developed a standardized protocol for measuring free radicals in smoke first by using a control cigarette and a technique called electron paramagnetic resonance spectrometry. They then applied the same protocol to 27 varieties of commercial cigarettes. The study found that the levels of gas-phase radicals ranged widely across the varieties while particulate-phase radicals showed less variability. An analysis of potential factors accounting for the differences found that highly ventilated cigarettes tended to produce lower levels of both gas- and particulate-phase free radicals. The researchers say their method could be used to assess people's exposure to free radicals, which can help determine potential health effects.


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Materials provided by American Chemical Society. Note: Content may be edited for style and length.


Journal Reference:

  1. Reema Goel, Zachary Bitzer, Samantha M. Reilly, Neil Trushin, Jonathan Foulds, Joshua Muscat, Jason Liao, Ryan J. Elias, John P. Richie. Variation in Free Radical Yields from U.S. Marketed Cigarettes. Chemical Research in Toxicology, 2017; DOI: 10.1021/acs.chemrestox.6b00359

Cite This Page:

American Chemical Society. "How to measure potentially damaging free radicals in cigarette smoke." ScienceDaily. ScienceDaily, 29 March 2017. <www.sciencedaily.com/releases/2017/03/170329145726.htm>.
American Chemical Society. (2017, March 29). How to measure potentially damaging free radicals in cigarette smoke. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2017/03/170329145726.htm
American Chemical Society. "How to measure potentially damaging free radicals in cigarette smoke." ScienceDaily. www.sciencedaily.com/releases/2017/03/170329145726.htm (accessed May 23, 2017).

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