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Potential new treatment strategy for neuroinflammation related to severe type of stroke

New research suggests that pharmcological blockade of a protein called TSPO reduces inflammation and brain edema in animal models of intracerebral hemorrhage

Date:
April 17, 2017
Source:
Federation of American Societies for Experimental Biology
Summary:
Scientists have discovered a potential new treatment to reduce the effects of intracerebral hemorrhage.
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Scientists have discovered a potential new treatment strategy to reduce the effects of intracerebral hemorrhage (ICH), a severe form of stroke where a blood vessel bursts and bleeds into the brain, causing life-threatening edema and neuroinflammation. Using mice, they found that a ligand of the TPSO protein called etifoxine reduces inflammation and brain edema in animal models. This research has been published online in The FASEB Journal.

"Targeting TSPO can restrict neuroinflammation and brain edema after ICH," said Qiang Liu, Ph.D., a researcher involved in the work at the Department of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, in Phoenix, Arizona. "TSPO ligands have the potential to serve as a new remedy for ICH."

Liu and colleagues made their discovery after inducing ICH in mice by administration of known effectors, with or without etoxifine. Etifoxine reduced leukocyte infiltration into the brain and microglial production of interleukin-6 and tumor necrosis factor alpha, both hallmarks of ICH. The ligand improved blood-brain-barrier integrity and diminished cell death.

"This is a very provocative new lead on ICH," said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal. "A cytokine axis in ICH is not new, but the notion that this TSPO ligand can do what it does is new, and very promising."


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Materials provided by Federation of American Societies for Experimental Biology. Note: Content may be edited for style and length.


Journal Reference:

  1. Minshu Li, Honglei Ren, Kevin N. Sheth, Fu-Dong Shi, Qiang Liu. A TSPO ligand attenuates brain injury after intracerebral hemorrhage. The FASEB Journal, 2017; fj.201601377RR DOI: 10.1096/fj.201601377RR

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Federation of American Societies for Experimental Biology. "Potential new treatment strategy for neuroinflammation related to severe type of stroke: New research suggests that pharmcological blockade of a protein called TSPO reduces inflammation and brain edema in animal models of intracerebral hemorrhage." ScienceDaily. ScienceDaily, 17 April 2017. <www.sciencedaily.com/releases/2017/04/170417131013.htm>.
Federation of American Societies for Experimental Biology. (2017, April 17). Potential new treatment strategy for neuroinflammation related to severe type of stroke: New research suggests that pharmcological blockade of a protein called TSPO reduces inflammation and brain edema in animal models of intracerebral hemorrhage. ScienceDaily. Retrieved April 28, 2017 from www.sciencedaily.com/releases/2017/04/170417131013.htm
Federation of American Societies for Experimental Biology. "Potential new treatment strategy for neuroinflammation related to severe type of stroke: New research suggests that pharmcological blockade of a protein called TSPO reduces inflammation and brain edema in animal models of intracerebral hemorrhage." ScienceDaily. www.sciencedaily.com/releases/2017/04/170417131013.htm (accessed April 28, 2017).